Study of Procalcitonin as a Biomarker and Its Correlation with Total Leucocyte Count in Patients with Sepsis
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Medical Science | India | Volume 8 Issue 11, November 2019

Study of Procalcitonin as a Biomarker and Its Correlation with Total Leucocyte Count in Patients with Sepsis

Rachana Warrier, Sourya Sourabh Mohakuda, Deeptika Agarwal, Harisankar KV

Introduction Bacterial sepsis is a common cause of morbidity and mortality in admitted patients and should receive prompt antibiotic treatment for better outcome. Fever can also be caused by noninfectious causes such as autoimmune diseases, malignancy, drugs, venous thromboembolism. Markers of systemic inflammation, such as CRP, erythrocyte sedimentation rate (ESR) have proven to be of limited utility due to their poor sensitivity and specificity for bacterial infection. Blood culture which is considered as the gold standard for diagnosing bacterial infection has a drawback in the form of a long turnaround time. Aim of the study: This study is aimed to evaluate the levels of procalcitonin (PCT) and its correlation with total leucocyte count (TLC) in adults presenting with features suggestive of sepsis. Methods: It is an observational study conducted in a zonal hospital in eastern part of India. 50 patients admitted with clinical diagnosis of sepsis were included. Patients already on treatment with antibiotics were excluded from the study. Correlation between procalcitonin level and total leucocyte count were studied using appropriate statistical tools. Results: Moderate positive correlation was found between TLC and procalcitonin (R: 0.458) and was statistically significant with a P value of 0.0008. Procalcitonin was found to be positive in all patients while TLC remained within normal range in 15 patients. Conclusion Procalcitonin can be used as an early biomarker for sepsis. PCT also gave an idea regarding the severity of infection. Moderate positive correlation was found between TLC and procalcitonin and was statistically significant.

Keywords: Sepsis, Procalcitonin, Total leucocyte count

Edition: Volume 8 Issue 11, November 2019

Pages: 378 - 381

Share this Article

How to Cite this Article?

Rachana Warrier, Sourya Sourabh Mohakuda, Deeptika Agarwal, Harisankar KV, "Study of Procalcitonin as a Biomarker and Its Correlation with Total Leucocyte Count in Patients with Sepsis", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20202494, Volume 8 Issue 11, November 2019, 378 - 381

307 PDF Views | 89 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Sepsis'

Research Paper, Medical Science, India, Volume 8 Issue 8, August 2019

Pages: 1336 - 1342

A Prospective Study on Clinical Profile & Mortality Determinants of Acute Kidney Injury in Patients Attending Tertiary Care Center in Southern Rajasthan

Dr. Gurdeep Kaur, Dr. Sanjay Parmar, Dr. Satish S

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 11, November 2019

Pages: 757 - 759

A Retrospective Study on Emergency Obstetric Hysterectomy in a Tertiary Care Hospital

Dr. Sweta Ghosh, Dr. Savitha T.S

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 12, December 2019

Pages: 1041 - 1043

A Study of Mean Platelet Volume as a Prognostic Marker in Sepsis

Dr. Harish.T. J, Dr. Balaraj K. P., Dr. Bharath.K, Dr. Prabhu.P

Share this Article

Research Paper, Medical Science, Poland, Volume 8 Issue 12, December 2019

Pages: 1716 - 1719

Invasive Lung Ventilation in the Patients with Sepsis and Mild Acute Respiratory Distress Syndrome Aggravates Sepsis Course

Oliynyk O.V., Slifirczyk A., Emyashev O.V., Pereviznyk B., Krenyev K. Yu.

Share this Article

Research Paper, Medical Science, Indonesia, Volume 8 Issue 9, September 2019

Pages: 1539 - 1542

Factors Affecting Neonatal Sepsis in Neonatal Intensive Care Unit (NICU) and Perinatology of Wangaya General Regional Denpasar Hospital

Fediah Chia Iskandar, I Wayan Bikin Suryawan

Share this Article

Similar Articles with Keyword 'Procalcitonin'

Research Paper, Medical Science, India, Volume 8 Issue 11, November 2019

Pages: 378 - 381

Study of Procalcitonin as a Biomarker and Its Correlation with Total Leucocyte Count in Patients with Sepsis

Rachana Warrier, Sourya Sourabh Mohakuda, Deeptika Agarwal, Harisankar KV

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 3, March 2019

Pages: 164 - 167

qSOFA or SIRS - The Better Predictor of Bacterial Sepsis in the Emergency Room

Abhiram A K, Bharath Prasad, Sreekrishnan TP, Sabrish B, Arun Kumar, Naveen Mohan, Dhanasekharan BS, Gireesh Kumar KP

Share this Article

Similar Articles with Keyword 'Total leucocyte count'

Research Paper, Medical Science, India, Volume 7 Issue 10, October 2018

Pages: 928 - 930

Comparison of Platelet Distribution width and Total Leucocyte Count in Diagnosis of Acute Appendicitis: A Retrospective Study

Dr Sachidanand Prabhu, Dr Saquib Sultan, Dr Abhishek A Jha

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 11, November 2019

Pages: 378 - 381

Study of Procalcitonin as a Biomarker and Its Correlation with Total Leucocyte Count in Patients with Sepsis

Rachana Warrier, Sourya Sourabh Mohakuda, Deeptika Agarwal, Harisankar KV

Share this Article
Top