International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064

Case Studies | Medical Sciences | Indonesia | Volume 8 Issue 8, August 2019

Efficacy of Combination Therapy with Natriuretic and Aquaretic Drugs Compared to A Conventional Diuretic Therapy as Treatment of Cirrhotic Patients with Ascites and Hyponatremia: An Evidence based Case Report

I Putu Yogi Sastrawan

Introduction: Cirrhotic patients with ascites and hyponatremia have a poor quality of life and high mortality. Classic diuretics such as furosemide and aldosterone antagonists spironolactone improve water retention and edema, but exacerbate hyponatremia in cirrhotic patients. Case illustration: 62 years old male presented to our hospital with severe abdominal pain and severe hyponatremia caused by cirrhosis hepatic. The patient already treated with a conventional diuretic therapy. We would like to investigate the efficacy between conventional diuretic therapy with natriuretic only and combination therapy with natriuretic and aquaretic drugs in treatment of our patient. Method: We search article in PubMed and Proquest, we found 3 eligible Randomized-Controlled Trial (RCT). We do critical appraisal using Center of Evidence-Based Medicine (CEBM) tool from Oxford University. Result: In three trial study, compared to a conventional therapy with only natriuretic drugs, a combination therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites. The six-month survival may be improved in cirrhotic patients with hyponatremia after tolvaptan short administration, Conclusion: combination therapy with natriuretic and aquaretic drugs is more effective compered to conventional therapy with only natriuretic drugs for patients with cirrhotic ascites

Keywords: Diuretic, tolvaptan, ascites, cirrhosis

Edition: Volume 8 Issue 8, August 2019

Pages: 352 - 355


How to Cite this Article?

I Putu Yogi Sastrawan, "Efficacy of Combination Therapy with Natriuretic and Aquaretic Drugs Compared to A Conventional Diuretic Therapy as Treatment of Cirrhotic Patients with Ascites and Hyponatremia: An Evidence based Case Report", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART2020240, Volume 8 Issue 8, August 2019, 352 - 355

82 PDF Views | 47 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Diuretic'

Comparative Studies, Medical Sciences, Indonesia, Volume 7 Issue 9, September 2018

Pages: 1061 - 1063

High-Dose Diuretic as Treatment of Refractory Ascites Compared with Paracentesis: An Evidence Based Case Report

Nicholas Wijayanto, I Made Suma Wirawan

Share this article

Case Studies, Medical Sciences, Indonesia, Volume 8 Issue 8, August 2019

Pages: 352 - 355

Efficacy of Combination Therapy with Natriuretic and Aquaretic Drugs Compared to A Conventional Diuretic Therapy as Treatment of Cirrhotic Patients with Ascites and Hyponatremia: An Evidence based Case Report

I Putu Yogi Sastrawan

Share this article

Similar Articles with Keyword 'ascites'

Comparative Studies, Medical Sciences, Indonesia, Volume 7 Issue 9, September 2018

Pages: 1061 - 1063

High-Dose Diuretic as Treatment of Refractory Ascites Compared with Paracentesis: An Evidence Based Case Report

Nicholas Wijayanto, I Made Suma Wirawan

Share this article

Research Paper, Medical Sciences, India, Volume 8 Issue 11, November 2019

Pages: 1441 - 1444

A Clinical Study of Nephrotic Syndrome with Special Reference to Serum Lipid Profile

Sravan Kumar Kusuma, Prathima Devi Surath, Indira Prabha

Share this article

Case Studies, Medical Sciences, India, Volume 8 Issue 2, February 2019

Pages: 1598 - 1600

HLH Syndrome: A Case Report

Sahithi Kilaru, Sadhna Sharma

Share this article

Case Studies, Medical Sciences, Indonesia, Volume 8 Issue 8, August 2019

Pages: 352 - 355

Efficacy of Combination Therapy with Natriuretic and Aquaretic Drugs Compared to A Conventional Diuretic Therapy as Treatment of Cirrhotic Patients with Ascites and Hyponatremia: An Evidence based Case Report

I Putu Yogi Sastrawan

Share this article

Research Paper, Medical Sciences, Albania, Volume 7 Issue 10, October 2018

Pages: 98 - 101

Serum Biomarkers for Early Detection of Portal Hypertension

Edlira Elezaj, Adriana Babameto

Share this article

Similar Articles with Keyword 'cirrhosis'

Case Studies, Medical Sciences, Indonesia, Volume 7 Issue 9, September 2018

Pages: 966 - 971

Perioperative Assessment of Diabetic Patient with Liver Cirrhosis Undergoing Surgery: A Case Report and Literature Review

Wandy Alvian, Suwandi Mario

Share this article

Research Paper, Medical Sciences, India, Volume 8 Issue 11, November 2019

Pages: 802 - 805

Clinical Profile of Patients Presenting with Upper Gastrointestinal Bleed in a Tertiary Care Hospital from South India

Dr. Varadaraj P Gokak, Dr. Santosh D Hajare, Dr. Amar Patil, Dr. Sharad Tukade, Dr. Santosh Bellari

Share this article

Comparative Studies, Medical Sciences, Indonesia, Volume 7 Issue 9, September 2018

Pages: 1061 - 1063

High-Dose Diuretic as Treatment of Refractory Ascites Compared with Paracentesis: An Evidence Based Case Report

Nicholas Wijayanto, I Made Suma Wirawan

Share this article

Research Paper, Medical Sciences, India, Volume 8 Issue 3, March 2019

Pages: 789 - 794

The Clinical Utility of Vitamin D Levels in Management of Treatment Naive Chronic HCV Infection

Hilal Ahmad Tali, Rubiya Ryhan, Irshad Ahmad Tali, Falak Ara

Share this article

Research Paper, Medical Sciences, India, Volume 8 Issue 2, February 2019

Pages: 1640 - 1644

Study of Relation of Renal Functions in Chronic Liver Disease Patients

Rohita Chitithoti, Ramireddy Krishna Chaitanya Reddy, Dorapudi S. Ch. Bhaskar, M. Sri Hari Babu

Share this article

Top