Research Paper | Biochemistry | Nigeria | Volume 8 Issue 11, November 2019
Hypoglycemic Effects of Aqueous and Ethanolic Extracts of Leptadenia hastata on Streptozotocin-Induced Diabetes Mellitus in Albino Rats
Panuel B., Nadro M.S., Abbaya H.Y
Single intra-peritoneal injection of 60 mg/kg body weight streptozotocin is known to induce diabetes mellitus and subsequently damage to the liver due to its hepato-toxic nature. The present study investigated the hypoglycemic and curative effects of Leptadenia hastata plant extracts conducted on 35 healthy male albino rats. The rats with blood glucose level above 200 mg/dl were randomly divided into seven (7) experimental groups of five rats each. Oral administration of 150 mg/kg body weight, 300 mg/kg body weight aqueous extract and 150 mg/kg body weight, 300 mg/kg body weight ethanolic extract were given to the diabetic rats for the period of 21 days. The fasting blood glucose was monitored at 7 days interval while markers of liver and kidney function were assayed at the end of 21 days treatment. The results revealed that oral administration of 300 mg/kg body weight ethanolic extract was found to be significant p
Keywords: Leptadenia hastata, Hypoglycemic effect, Diabetes mellitus, Streptozotocins
Edition: Volume 8 Issue 11, November 2019
Pages: 152 - 158
How to Cite this Article?
Panuel B., Nadro M.S., Abbaya H.Y, "Hypoglycemic Effects of Aqueous and Ethanolic Extracts of Leptadenia hastata on Streptozotocin-Induced Diabetes Mellitus in Albino Rats", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART202023311, Volume 8 Issue 11, November 2019, 152 - 158
143 PDF Views | 126 PDF Downloads
Similar Articles with Keyword 'Hypoglycemic effect'
Research Paper, Biochemistry, India, Volume 7 Issue 4, April 2018
Pages: 771 - 774Hypoglycemic Effect of Mixed Herbal Extract and Vitamin E in Biphenol A Induced Albino Rats
V. Sandhiya, Dr. M. Sendhilvadivu
Research Paper, Biochemistry, Nigeria, Volume 8 Issue 11, November 2019
Pages: 152 - 158Hypoglycemic Effects of Aqueous and Ethanolic Extracts of Leptadenia hastata on Streptozotocin-Induced Diabetes Mellitus in Albino Rats
Panuel B., Nadro M.S., Abbaya H.Y
Similar Articles with Keyword 'Diabetes mellitus'
Research Paper, Biochemistry, Iraq, Volume 6 Issue 3, March 2017
Pages: 2000 - 2003The Concentration of Adrenomedullin in Obese Subjects with and without Diabetes Compared with Healthy Control
Shaimaa S. Mutlak, Mohammed S Kadhim, Nada K. Al Hussaini
Research Paper, Biochemistry, India, Volume 9 Issue 4, April 2020
Pages: 1258 - 1261Study on the Status of Lipid Profiles as an Indicator for Complications in Type - 2 Diabetes Mellitus
Devendra Nath Mishra, B. K. Agrawal, Arya Desh Deepak, Dhirendra Kumar Shukla, Kanchan Singh, Sadhna Ajay, A.K. Singh, Tapasi Barai
Research Paper, Biochemistry, Nigeria, Volume 4 Issue 2, February 2015
Pages: 2412 - 2416Nicotinamide Ameliorates Serum C-Peptide and Brain Tryptophan Levels in STZ-Induced Diabetic Sprague- Dawley Rats
O.A.T. Ebuehi, C. Fregene, G.O. Ihegboro
Research Paper, Biochemistry, Netherlands, Volume 3 Issue 7, July 2014
Pages: 1513 - 1515Comparison of Fasting Plasma Glucose among Smoking and Non Smoking Medical Student Population
Raghvendra Tey, Poornima Manjrekar, Vivian Dsouza
Review Papers, Biochemistry, Afghanistan, Volume 7 Issue 2, February 2018
Pages: 1163 - 1172Molecular Mechanisms of Diabetic Nephropathy, General Preventive Measures and Novel Therapeutic Strategies
Najia Sherzay