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Research Paper | Pharmaceutical Science | India | Volume 9 Issue 3, March 2020
Consideration of Pre-Formulation Parameters to Develop Solid Dosage Form
Keshav Jindal | Manjot Narula
Abstract: As the name indicates, Pre means before and Formulation means Processing. When any dosage form is to be designed, researchers are not aware about properties of drug substance and this is a crucial step to evaluate the drug substance for better dosage form design. Pre-formulation studies are to be conducted before designing dosage form. Pre-formulation studies include bulk characteristics, solubility characteristics and stability characteristics of drug substance. With the help of these studies a researcher would come to know about the physical and chemical properties of drug substance. A better dosage form can be designed by considering the evaluation outcomes of conducted pre-formulation parameters. This will furnish the pharmacokinetic and pharmacodynamic effects of designed dosage form and dosage form can show its desired therapeutic effect for patients. This whole protocol is known as Pre-formulation. Parameters which are evaluated for processing of dosage forms are called Pre-formulation parameters.
Keywords: Conventional dosage form, Non-conventional dosage form, Bulk characteristics, Angle of repose, Crystalline
Edition: Volume 9 Issue 3, March 2020,
Pages: 775 - 780
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