Research Paper | Gynaecology | India | Volume 8 Issue 7, July 2019
Atherogenic Lipid Profile in Early Pregnancy Associated with Pre-Eclampsia
Dr. Vani, Dr. M. Kousica
Abstract: Preeclampsia, a syndrome defined by hypertension and proteinuria is associated with increased maternal mortality and morbidity in United States and worldwide. There is no clear distinction between normotensive and preeclamptic pregnancies in terms of pathogenic factors and disease mechanisms. However, various factors are implicated in the pathogenesis of pre-eclampsia including genetic, immune, vascular, and oxi- dative stress. These have led to identification of potential candidate markers from cross-sectional studies. Maternal plasma lipids are significantly elevated during pregnancy. Women who develop preeclampsia experience even more dramatic lipid changes. Most, although not all, case-control studies have shown a preeclampsia dyslipi- demic pattern of increased triglycerides, cholesterol, low- density lipoprotein (LDL) and decreased high-density lipoprotein (HDL) concentrations. Inferences from these studies are limited by the fact that plasma lipid profiles were determined using blood samples collected after the diagnosis of preeclampsia. Evidence from few available prospective cohort studies suggest that women destined to develop the disorder are more likely to have elevated plasma triglycerides and decreased HDL cholesterol concentrations compared with their normotensive counterparts. However, results are not consistent, and investigators generally have not adjusted for possible confounding factors. We therefore used available information and plasma specimens from an ongoing prospective cohort study of women receiving prenatal care before 16 weeks gestation to examine whether varying concentrations of maternal plasma lipids and lipoproteins, measured in early pregnancy, are independently associated with an increased risk of preeclampsia.
Keywords: Plasma lipids, obesity, pregnancy, pre- eclampsia
Edition: Volume 8 Issue 7, July 2019,
Pages: 1884 - 1885
How to Cite this Article?
Dr. Vani, Dr. M. Kousica, "Atherogenic Lipid Profile in Early Pregnancy Associated with Pre-Eclampsia", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20199342, Volume 8 Issue 7, July 2019, 1884 - 1885
How to Share this Article?
Similar Articles with Keyword 'obesity'
Effect of BMI on Fetomaternal Outcome
Dr Nalini Anand, Dr Aditi Samdarshi Bhardwaj
Post Menopausal Bleeding: An Analytic Study of 100 Cases
Nirupama V, Suneetha Y, Prabha Devi K
Similar Articles with Keyword 'pregnancy'
Necrobiosis of Fibroid Causing Acute Abdomen in a Nongravid Uterus - Case Report
Dr. Komal Vijaywargiya, Dr. Apoorva Choudhary, Dr. Aayushi Ruia
Case Report on Consanguineous Marriage
Pramila D' Souza; Sonia Karen Liz Sequera
Similar Articles with Keyword 'pre eclampsia'
Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome
Unmesh Suresh Santpur, Madhavi U Santpur, Sushma
Successful Pregnancy in a Case of Bicornuate Uterus with Pre Eclampsia and IUGR - A Case Report
SasikalaMootha, Usharani Bathula
Similar Articles with Keyword 'Plasma'
The Incidence of the Third Trimester Complications in Gestational Diabetes in our Hospital
Migena PRIFTI MD, Arben HAXHIHYSENI MD PhD
Study of Maternal Morbidity Associated with Morbidly Adherent Placenta
Dr. Deepthi. D, Dr. Deepa. Kanagal. V, Dr. Abhilash Vasanth