Case Studies | Gynaecology | India | Volume 8 Issue 7, July 2019
Cholestasis of Pregnancy
D.R.T.G.Revathy, Dr. B. Sindhuja
Intrahepatic cholestasis of pregnancy (ICP) appears in the second and third trimester of pregnancy and is characterized by pruritus and an increase of serum bile acid concentration. Cholestasis is associated with many hepatic-biliary disorders that produce extrahepatic biliary tract obstruction and/or intrahepatic biliary perturbation. A key symptom associated with cholestasis is pruritus, and could range in severity from mild to moderate (i.e. where sleep is disrupted) and to extreme (i.e. when the lifestyle of the patient is completely disrupted). It is often generalized but predominates on the palms and soles and manifests more violently at night. Pruritus may precede laboratory abnormalities. Total serum concentration of bile acid increase in cholestasis of pregnancy and may be the first or only laboratory abnormality. Other laboratory results reflecting cholestasis may also be present. These include increases in serum alkaline phosphatase (ALKP), total and direct bilirubin concentration. However, uncommonly, serum levels of gamma- glutamyl transpeptidase (GGT) are normal or slightly elevated, which is unusual in many other forms of cholestatic liver disease in which GGT levels are similar to other cholestatic markers. Most women are diagnosed in the second or third trimester of pregnancy.
Keywords: pregnancy, cholestasis, pruritis
Edition: Volume 8 Issue 7, July 2019
Pages: 492 - 493
How to Cite this Article?
D.R.T.G.Revathy, Dr. B. Sindhuja, "Cholestasis of Pregnancy", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20199337, Volume 8 Issue 7, July 2019, 492 - 493
173 PDF Views | 133 PDF Downloads
Similar Articles with Keyword 'pregnancy'
Case Studies, Gynaecology, India, Volume 4 Issue 3, March 2015
Pages: 2457 - 2459Case Report on Consanguineous Marriage
Pramila D' Souza; Sonia Karen Liz Sequera
Case Studies, Gynaecology, India, Volume 6 Issue 6, June 2017
Pages: 1431 - 1433Anaesthetic Management of Primigravida with Ovarian Cyst for Emergency Laparotomy
Dr. Krishna Patel; Dr. Aishwarya Bandewar; Dr. Olvyna D'souza
Case Studies, Gynaecology, India, Volume 6 Issue 8, August 2017
Pages: 1926 - 1927Anesthesia Management in a Case of Ectopic Pregnancy with Severe Anemia
Dr. Bhumika Kathiriya; Dr. Hemesh Shewale; Dr. Olvyna D'Souza; Dr. Samrajini Ganguli
Research Paper, Gynaecology, India, Volume 7 Issue 11, November 2018
Pages: 1802 - 1803Pregnancy Against all Odds - A Successful Pregnancy in a Case of Abdominal Kochs
Dr. Sachin Paprikar, Dr. ReenaJatin Wani, Dr. Rashmi Jalvee
Masters Thesis, Gynaecology, India, Volume 9 Issue 9, September 2020
Pages: 384 - 391Nifedipineversus Isoxsuprine for Suppression of Preterm Labour - A Comparative Randomised Study
Prashant Pawar, Amol Pawar