Cholestasis of Pregnancy
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Case Studies | Gynaecology | India | Volume 8 Issue 7, July 2019

Cholestasis of Pregnancy

D.R.T.G.Revathy, Dr. B. Sindhuja

Intrahepatic cholestasis of pregnancy (ICP) appears in the second and third trimester of pregnancy and is characterized by pruritus and an increase of serum bile acid concentration. Cholestasis is associated with many hepatic-biliary disorders that produce extrahepatic biliary tract obstruction and/or intrahepatic biliary perturbation. A key symptom associated with cholestasis is pruritus, and could range in severity from mild to moderate (i.e. where sleep is disrupted) and to extreme (i.e. when the lifestyle of the patient is completely disrupted). It is often generalized but predominates on the palms and soles and manifests more violently at night. Pruritus may precede laboratory abnormalities. Total serum concentration of bile acid increase in cholestasis of pregnancy and may be the first or only laboratory abnormality. Other laboratory results reflecting cholestasis may also be present. These include increases in serum alkaline phosphatase (ALKP), total and direct bilirubin concentration. However, uncommonly, serum levels of gamma- glutamyl transpeptidase (GGT) are normal or slightly elevated, which is unusual in many other forms of cholestatic liver disease in which GGT levels are similar to other cholestatic markers. Most women are diagnosed in the second or third trimester of pregnancy.

Keywords: pregnancy, cholestasis, pruritis

Edition: Volume 8 Issue 7, July 2019

Pages: 492 - 493

Share this Article

How to Cite this Article?

D.R.T.G.Revathy, Dr. B. Sindhuja, "Cholestasis of Pregnancy", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20199337, Volume 8 Issue 7, July 2019, 492 - 493

119 PDF Views | 80 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'pregnancy'

Masters Thesis, Gynaecology, India, Volume 9 Issue 9, September 2020

Pages: 384 - 391

Nifedipineversus Isoxsuprine for Suppression of Preterm Labour - A Comparative Randomised Study

Prashant Pawar, Amol Pawar

Share this Article

Case Studies, Gynaecology, India, Volume 4 Issue 3, March 2015

Pages: 2457 - 2459

Case Report on Consanguineous Marriage

Pramila D' Souza; Sonia Karen Liz Sequera

Share this Article

Research Paper, Gynaecology, India, Volume 5 Issue 2, February 2016

Pages: 1778 - 1781

Antihypertensives in Preeclampsia ? A Retrospective Analysis

Dr. Nandini G, Dr. Jessica Fernandes

Share this Article

Research Paper, Gynaecology, India, Volume 4 Issue 11, November 2015

Pages: 1285 - 1286

A Rare Case of Secondary Abdominal Pregnancy

Dr. Aparna BL, Dr. Shalini B, Dr. Priyadarshani D, Dr. Romita N, Dr. Ranjit Singh L

Share this Article

Case Studies, Gynaecology, India, Volume 6 Issue 6, June 2017

Pages: 1431 - 1433

Anaesthetic Management of Primigravida with Ovarian Cyst for Emergency Laparotomy

Dr. Krishna Patel; Dr. Aishwarya Bandewar; Dr. Olvyna D'souza

Share this Article
Top