International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 193

Research Paper | Biomedical Sciences | Egypt | Volume 8 Issue 6, June 2019


Role of Mesenchymal Stem Cells in Breast Cancer Progression in vitro

Khalil A. Elhalfawy, Bahgat A. Elfiky, Sara Saber


Abstract: The role of Mesenchymal stem cells in tumor development is still controversial. MSCs may promote tumor progression through immune modulation, but other tumor suppressive effects of MSCs have also been described. The discrepancy between these results may arise from issues related to different tissue sources, individual donor variability, and injection timing of MSCs. The expression of critical receptors such as Toll-like receptor is variable a teach time point of treatment, which may also determine the effects of MSCs on tumor progression. However, factors released from malignant cells, as well as surrounding tissues and the vasculature, are still regarded as a black box. Thus, it is still difficult to clarify the specific role of MSCs in cancer development. Whether MSCs support or suppress tumor progression is currently unclear, but it is clear that systemically administered MSCs can be recruited and migrates toward tumors. These findings are important because they can be used as a basis for initiating studies to explore the incorporation of engineered MSCs as novel anti-tumor carriers, for the development of tumor-targeted therapies.


Keywords: CD105 Mesenchymal stem cells, Bax, Bcl2, P53, CASP9 Tumor markers and Immunophenotyping


Edition: Volume 8 Issue 6, June 2019,


Pages: 195 - 199


How to Cite this Article?

Khalil A. Elhalfawy, Bahgat A. Elfiky, Sara Saber, "Role of Mesenchymal Stem Cells in Breast Cancer Progression in vitro", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20198223, Volume 8 Issue 6, June 2019, 195 - 199

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'stem'

Downloads: 0

Research Paper, Biomedical Sciences, Congo, Volume 10 Issue 8, August 2021

Pages: 645 - 648

Evolutionary Profile of Drepanocytic Patients Followed at the National Drepanocytosis Reference Centre (CNRDr) Congo Brazzaville

Edwige Paola Chancelle LOUANGA NANITELAMIO, Serge Oscar MOKONO, Chaldam Jesp?re MBANI, Olivia Galiba Atipo - Tsiba, Fabien Roch NIAMA, Etienne MOKONDJIMOBE, Donatien MOUKASSA, Ange Antoine ABENA, Alexis ELIRA DOKEKIAS

Share this Article

Downloads: 4

Review Papers, Biomedical Sciences, Indonesia, Volume 10 Issue 6, June 2021

Pages: 894 - 897

Potency of Secretome in Reproductive Regenerative Medicine

Megaratni Sandhi, Wimpie Pangkahila

Share this Article

Similar Articles with Keyword 'cells'

Downloads: 0

Research Paper, Biomedical Sciences, Indonesia, Volume 10 Issue 8, August 2021

Pages: 852 - 856

Administration of Myrmecodia pendans Ethanol Extract Cream Prevented Elevation of Keratinocyte Apoptosis and Number of Macrophages in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B (UVB)

Diana Utami, Wimpie Pangkahila, I Gusti Made Aman

Share this Article

Downloads: 2

Research Paper, Biomedical Sciences, Indonesia, Volume 10 Issue 6, June 2021

Pages: 844 - 847

The Administration of Zinc Inhibited the Decrease of Leydig Cell and Testosterone Level in Male Wistar Rats (Rattus Norvegicus) that are Exposed to Electric Cigarette Smoke

Novita Indah Permatasari, Wimpie I. Pangkahila, Luh Putu Indrayani Maker

Share this Article
Top