Inoculation of Helicobacter Pylori Bali03isolate as a Risk Factor in Increasingthe Severity of Gastritis Compared to ATCC 43504 Isolatein Balb/C Mice
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Medical Science | Indonesia | Volume 8 Issue 5, May 2019

Inoculation of Helicobacter Pylori Bali03isolate as a Risk Factor in Increasingthe Severity of Gastritis Compared to ATCC 43504 Isolatein Balb/C Mice

Sagita Dewi NLG, Susraini AAAN, Herman Saputra, Sri Mahendra Dewi IGA, Iin Indrayani Maker LP, Muliarta IM

Gastritis is a common gastrointestinal health problem, where H. pylori infects nearly 50% of the world's population. The prevalence of H. pylori infection in developing countries is higher compared to developed countries. H. pylori causes gastric inflammation in all infected patients. The aim of this study was to find out the mean difference of gastritis degree and prove the degree of gastritis is more severe in BALB/c mice inoculated with H. pylori Bali 03 isolate compared to ATCC 43504 isolate. This study was an experimental study with a randomized posttest only control group design, in 36 male BALB / c mice which were divided into 2 groups : group I was inoculated with H. pylori ATCC 43504 isolate, while group II was inoculated with Bali 03 isolates. The study was conducted at the Department of Anatomical Pathology, Sanglah Hospital, Denpasar, and the Biomedical Laboratory of NTB Province Hospital, Mataram, from February to April 2019. In the eighth week, all samples were euthanized, then a gastric resection is performed to assess the gastritis degrees according to revised Sydney system by conventional histopathology and immunohistochemistry. Mice inoculated by H. pylori ATCC 43504 isolate had the incidence of mild and moderate gastritis, 16 (88.8%) and 2 (11.1%) respectively, while mice inoculated by H. pylori Bali 03 isolate had the incidence of mild and moderate gastritis 7 (38.8%) and 11 (61.1%) respectively. The mean difference of gastritis degree showed that the average gastritis score in mice inoculated by H. pylori ATCC 43504 isolate was 3.88; while mice inoculated by H. pylori Bali 03 isolate was 6.22, with p values: 0,000. The difference in the proportion of gastritis degrees with x2 test showed that H. pylori Bali 03 isolate caused severer gastritis degree by 5.5 times compared to H. pylori ATCC 43504 isolate (RR 5.5; 95% IK 1.41-21.37).

Keywords: H pylori, ATCC 43504, Bali 03, Gastritis

Edition: Volume 8 Issue 5, May 2019

Pages: 1919 - 1922

Share this Article

How to Cite this Article?

Sagita Dewi NLG, Susraini AAAN, Herman Saputra, Sri Mahendra Dewi IGA, Iin Indrayani Maker LP, Muliarta IM, "Inoculation of Helicobacter Pylori Bali03isolate as a Risk Factor in Increasingthe Severity of Gastritis Compared to ATCC 43504 Isolatein Balb/C Mice", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20197925, Volume 8 Issue 5, May 2019, 1919 - 1922

132 PDF Views | 101 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'H pylori'

Research Paper, Medical Science, Indonesia, Volume 7 Issue 9, September 2018

Pages: 1008 - 1010

Prevalence of Helicobacter Pylori in Wangaya Regional General Hospital Denpasar, Bali from January to December 2017

I Gede Komang Aditya Permana, Robert

Share this Article

Research Paper, Medical Science, Indonesia, Volume 8 Issue 5, May 2019

Pages: 1919 - 1922

Inoculation of Helicobacter Pylori Bali03isolate as a Risk Factor in Increasingthe Severity of Gastritis Compared to ATCC 43504 Isolatein Balb/C Mice

Sagita Dewi NLG, Susraini AAAN, Herman Saputra, Sri Mahendra Dewi IGA, Iin Indrayani Maker LP, Muliarta IM

Share this Article
Top