International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 133

Comparative Studies | Pathology | India | Volume 8 Issue 5, May 2019


Early Diagnostic Markers for Neonatal Sepsis - Haematological Scoring System, C-Reactive Protein and Procalcitonin

Dr Malvika Gaur | Dr Arathi C.A.


Abstract: Background: Neonatal sepsis is associated with high mortality and morbidity rate, as the clinical manifestations are nonspecific. Therefore, the need arises for early diagnostic markers of neonatal sepsis like Haematological scoring system (HSS), C-Reactive protein (CRP), Procalcitonin (PCT). Aim: To evaluate the role of diagnostic parameters HSS, CRP and PCT in the early detection of neonatal sepsis. Methods: 50 cases of neonatal sepsis were studied, HSS was calculated as per the 7 point Rodwell et al scoring system. PCT was calculated by the semi-quantitative kit. Statistical analysis: The results were compared with each other (comparative study design), with the gold standard (blood culture). Specificity, sensitivity, PPV & NPV were calculated. Result: Blood culture was Positive - 46 % cases, negative - 54 % cases, most common isolate obtained Coagulase negative staphylococcus aureus (CONS) 47.3 % cases, Staphylococcus aureus (34.78 % cases). HSS obtained Sepsis very likely - 56 % cases, Sepsis possible - 40 % cases, Sepsis unlikely - 4 % cases. CRP results obtained positive results - 60 % cases, negative - 40 % cases. PCT results were positive - 86 % cases and negative - 14 % cases. Conclusion: Among the various screening tests, PCT has higher sensitivity of 91.3 % as compared to CRP (73.9 %), HSS (65.2 %). Thus, PCT is a better marker for screening neonatal sepsis. However it is not very specific, can be raised in various other conditions.


Keywords: Blood culture, HSS, Neonatal sepsis, PCT


Edition: Volume 8 Issue 5, May 2019,


Pages: 716 - 720


How to Cite this Article?

Dr Malvika Gaur, Dr Arathi C.A., "Early Diagnostic Markers for Neonatal Sepsis - Haematological Scoring System, C-Reactive Protein and Procalcitonin", International Journal of Science and Research (IJSR), Volume 8 Issue 5, May 2019, pp. 716-720, https://www.ijsr.net/get_abstract.php?paper_id=ART20197640

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'Neonatal sepsis'

Downloads: 107

Research Paper, Pathology, India, Volume 8 Issue 6, June 2019

Pages: 936 - 944

Early Diagnosis of Neonatal Sepsis using Hematological Scoring System in Resource limited Set Up

Dr Priyanka Gupta [2] | Dr Sanjay Khare | Dr Pramod Mishra

Share this Article

Downloads: 140

M.Tech / M.E / PhD Thesis, Pathology, India, Volume 7 Issue 3, March 2018

Pages: 290 - 294

A Study of Neutrophil Volume, Conductance and Scattergram Parameters in early detection of Neonatal Sepsis

Dr. Vijay Kapse [3] | Dr. Jayanti Chandrakar [2] | Dr. Renuka Gahine [5] | Dr. Girish Suman

Share this Article


Top