Research Paper | Biochemistry | India | Volume 8 Issue 5, May 2019
Evaluation of Association between Serum HS-CRP and Lipid Profile in Type 2 Diabetes Mellitus
Dr. Premjeet Kaur, Dr. Naresh Malhotra
High sensitive C-reactive protein (hs-CRP) is an established marker of low grade systemic inflammation. A chronic low-grade inflammatory condition has been proposed to underline increased risk for atherosclerotic disease, including renal dysfunction and cardiovascular disease suggesting a possible link between the high incidence of macrovascular complications and diabetes. Insulin resistance results in high concentrations of serum lipids in diabetics due to increased mobilization of free fatty acids from fat depots. Because serum hs-CRP and serum lipid profile reflect closely related component of the same disease process, a strong relationship between these variables may be anticipated. We selected 50 patients of Type-2 diabetes mellitus and 50 normal healthy individuals to evaluate this association. Serum estimations showed a significant increase (p< 0.001) in hs-CRP, Total cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL) in diabetics when compared to controls. In contrast there was significant decrease (p< 0.001) in HDL-C in diabetics. The statistical analysis depicted a non significant correlation between serum hs-CRP and total cholesterol ( p= 0.909, r=0.017), serum triglyceride (p=0.294, r=0.151) and serum HDL (p=0.724, r=-0.051) in type 2 diabetic patients. This finding may therefore, suggest that hs-CRP act as an independent marker for cardiovascular risk factor.
Keywords: Type 2 diabetes diabetes, hs-CRP, lipid profile
Edition: Volume 8 Issue 5, May 2019
Pages: 160 - 162
How to Cite this Article?
Dr. Premjeet Kaur, Dr. Naresh Malhotra, "Evaluation of Association between Serum HS-CRP and Lipid Profile in Type 2 Diabetes Mellitus", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20197571, Volume 8 Issue 5, May 2019, 160 - 162
130 PDF Views | 92 PDF Downloads
Similar Articles with Keyword 'lipid profile'
Study on the Status of Lipid Profiles as an Indicator for Complications in Type - 2 Diabetes Mellitus
Devendra Nath Mishra, B. K. Agrawal, Arya Desh Deepak, Dhirendra Kumar Shukla, Kanchan Singh, Sadhna Ajay, A.K. Singh, Tapasi Barai
Olive Leaves (Olea europaea, L.) Improve Insulin-like Growth Factor (IGF) System Implications Induced by High Fat-High Sucrose Diet
Amira Abd El-Rhman, Eman Hassan
Lipid Profile of Kashmiri Type 2 Diabetic Patients
Mohd Urfan Wani, Imran Shafi, Tabasum Rashid
Dyslipidemia and its Correlation with Creatinine Clearence in Chronic Kidney Disease
Dr. J. Latha, Dr. N. Santhi
Alterations in Antioxidant Defense System and Oxidative Damage in Experimental Hepatorenal Toxicity Induced by Isoniazid and Rifampicin in Rats: Effect of N-Acetyl Cysteine and White Tea Extract
Rokaya M. Hussein, Samy A. AbdelAzim, Amany H. Mahmoud Elgoly, Mohamed R. Rizk