Varied Clinical Manifestation of Congenital Afibrinogenemia: From Thrombosis to Intramedullary Hemorrhage - A Case Series of 7 Patients
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
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ISSN: 2319-7064



Case Studies | Hematology | India | Volume 8 Issue 5, May 2019

Varied Clinical Manifestation of Congenital Afibrinogenemia: From Thrombosis to Intramedullary Hemorrhage - A Case Series of 7 Patients

Dr. Shailesh H Bamborde, Dr. Farah Jijina, Dr. Chandrakala.S, Dr. Shrimati Shetty, Dr. Rajesh Patil, Dr. Nilesh Wasekar, Dr. Vinod Patil, Dr. Shruti Mantri

Congenital afibrinogenemia is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen in circulation. There are about 250 cases reported in the world literature. Afibrinogenemia and hypofibrinogenemia represent the homozygous and heterozygous states, respectively, for mutations affecting plasma fibrinogen concentration. Here we report 7 cases with varied clinical manifestations at presentation. In our case series, 3 patients presented with bleeding symptoms, one patient with bleeding as well as thrombosis and one with recurrent abortions.

Keywords: afibrinogenemia, fibrinogen, thrombosis, bleeding, abortion

Edition: Volume 8 Issue 5, May 2019

Pages: 55 - 59

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How to Cite this Article?

Dr. Shailesh H Bamborde, Dr. Farah Jijina, Dr. Chandrakala.S, Dr. Shrimati Shetty, Dr. Rajesh Patil, Dr. Nilesh Wasekar, Dr. Vinod Patil, Dr. Shruti Mantri, "Varied Clinical Manifestation of Congenital Afibrinogenemia: From Thrombosis to Intramedullary Hemorrhage - A Case Series of 7 Patients", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20197406, Volume 8 Issue 5, May 2019, 55 - 59

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