Research Paper | Biomedical Sciences | Indonesia | Volume 8 Issue 5, May 2019
The Effects of Noni (Morinda Citrifolia) Ethanol Extract Cream on Collagen Deposition in Incisional Wound Healing of Male Wistar Rats
Daniel Setiawan Lay, I Wayan Sugiritama, Ni Made Linawati, I.G.K. Nyoman Arijana
Incisional wounds, such as post-surgery wounds are traumas that could reduce quality of life of patients and cause many complications. While often disturbed by many factors, reactive oxygen species (ROS) and unending inflammation stage is two of many contributing factors that can delay wound healing. Therefore, new natural phytochemical source is needed to accelerate the healing of wounds and minimize the risk of complications. On this experimental analytic research with control group post-test research design, twenty-four male wistar rats divided into four groups. The first group is P1 (Incisional Wound + Placebo Cream) as control, P2 (Incisional Wound + 5 % Noni extract cream), P3 (Incisional Wound + 10 % Noni extract cream), P4 (Incisional Wound + 20 % Noni extract cream). At the end of fifteenth day of wound healing, all samples are terminated and the scar tissue is observed under the microscope with Picrosirius Red (PSR) staining. Groups that are treated with concentrations of 5 %, 10 %, and 20 % Noni extract cream have higher mean percentage of collagen deposition compared with the placebo group. Mean percentage of group P1 is 42, 49 %, P2 is 54, 18 %, P3 is 64, 89 %, and P4 as high as 72, 22 %. Through this study, topical application of noni ethanol extract cream on incisional wounds of wistar rats gained an evidence on accelerating healing and increasing collagen deposition of the wounds compared to base cream applications only.
Keywords: Noni, quercetin, incisional wound, collagen
Edition: Volume 8 Issue 5, May 2019
Pages: 419 - 423
How to Cite this Article?
Daniel Setiawan Lay, I Wayan Sugiritama, Ni Made Linawati, I.G.K. Nyoman Arijana, "The Effects of Noni (Morinda Citrifolia) Ethanol Extract Cream on Collagen Deposition in Incisional Wound Healing of Male Wistar Rats", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20197049, Volume 8 Issue 5, May 2019, 419 - 423
149 PDF Views | 84 PDF Downloads
Similar Articles with Keyword 'quercetin'
Masters Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 9, September 2020
Pages: 636 - 640Administration of Papaya (Carica Papaya Linn) Seeds Extract Cream 40% Decrease MMP-1 Expression and Increase Dermal Collagen of Male Wistar Rats (Rattus Norvegicus) Exposed to UV-B Ray
Dyah Ratih Pramesti, Anak Agung Gde Wiraguna, A.A.A.N. Susraini
Research Paper, Biomedical Sciences, Indonesia, Volume 8 Issue 5, May 2019
Pages: 419 - 423The Effects of Noni (Morinda Citrifolia) Ethanol Extract Cream on Collagen Deposition in Incisional Wound Healing of Male Wistar Rats
Daniel Setiawan Lay, I Wayan Sugiritama, Ni Made Linawati, I.G.K. Nyoman Arijana
Similar Articles with Keyword 'collagen'
Masters Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 9, September 2020
Pages: 636 - 640Administration of Papaya (Carica Papaya Linn) Seeds Extract Cream 40% Decrease MMP-1 Expression and Increase Dermal Collagen of Male Wistar Rats (Rattus Norvegicus) Exposed to UV-B Ray
Dyah Ratih Pramesti, Anak Agung Gde Wiraguna, A.A.A.N. Susraini
M.Tech / M.E / PhD Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 8, August 2020
Pages: 1082 - 1085The Application of 5.4% Lime Peel Etanol Extract Cream (Citrus aurantifolia) inhibited the Increase of Matrix Metalloproteinase-1 Expression and the Decreased Amount of Collagen in Guinea Pigs (Cavia Porcellus) that were exposed to Ultraviolet B Rays
Dwi Ariyanti
Research Paper, Biomedical Sciences, Indonesia, Volume 8 Issue 5, May 2019
Pages: 1883 - 1886Ethanol Extract of Black Rice (Oryza sativa L) Bran Reduced Expression of RAGE in Skin of Wistar Rat Exposed with UVA and UVB
Liza Widjaja, Wimpie Pangkahila, Anak Agung Gde Putra Wiraguna, Ida Bagus Putra Manuaba
Research Paper, Biomedical Sciences, Indonesia, Volume 8 Issue 5, May 2019
Pages: 419 - 423The Effects of Noni (Morinda Citrifolia) Ethanol Extract Cream on Collagen Deposition in Incisional Wound Healing of Male Wistar Rats
Daniel Setiawan Lay, I Wayan Sugiritama, Ni Made Linawati, I.G.K. Nyoman Arijana