International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 142

Research Paper | Medical Science | India | Volume 8 Issue 3, March 2019


Pre-Operative Prophylactic Levosimendan for on Pump Coronary Artery Bypass Grafting in Patients with Low Ejection Fraction

Satish Kumar Mishra [3] | Sachin Shouche [2]


Abstract: Background: On pump CABG is associated with more complete revascularization as compared to OPCAB but due to the use of CPB Machine it is associated with severe Inflammatory Response eventually leading to adverse effects, especially in patients with low ejection fraction & appropriate selection of Inotropes plays a very important role in perioperative management of these patients. Aim & Objective: To study the effects of Levosimendan when it is used prophylactically in perioperative period in patients with low ejection fraction undergoing On Pump CABG. Material & Method: After Institutional ethics Committee approval and obtaining written informed consent, 60 patients undergoing elective On Pump CABG were randomly divided into two groups (n=30 each). Group A patients were started on Injection Levosimendan Infusion @ 0.1 g/kg/min in operation theatre & hemodynamic parameters such as Heart Rate, Invasive Blood Pressure, Pulmonary Capillary Wedge Pressure (PCWP), Cardiac Index (CI), Pulse Oximetry, Nasopharyngeal Temperature Capnography, Urine Output & Arterial Blood Gas including Serum Lactate were monitored at To (baseline), T1 (15 mins after OM & PDA anastomoses), T2 (at end of surgery), T3 ( 6 hrs after surgery), T4 ( 12 hrs after surgery), & T5 ( 24 hrs after surgery). Results: In group A CI was significantly higher & PCWP was significantly lower compared to group B. In group B there was significantly reduction in MAP at T1 & there was also a significantly number of patients who developed Acute Kidney Injury compared to group A. Group A patients had lower number of POAF, lesser need for IABP, compared to group B. Conclusion: In patients with low ejection fraction who are undergoing On Pump CABG, Prophylactic preoperative Levosimendan is associated with decreased hemodynamic perturbations & are associated with favorable clinical outcome.


Keywords: OMObtuse Marginal, PDAposterior Descending Artery, LCOSLow Cardiac Output Syndrome, POAFPost Op atrial Fibrillation


Edition: Volume 8 Issue 3, March 2019,


Pages: 1312 - 1315

Pre-Operative Prophylactic Levosimendan for on Pump Coronary Artery Bypass Grafting in Patients with Low Ejection Fraction


How to Cite this Article?

Satish Kumar Mishra, Sachin Shouche, "Pre-Operative Prophylactic Levosimendan for on Pump Coronary Artery Bypass Grafting in Patients with Low Ejection Fraction", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20196401, Volume 8 Issue 3, March 2019, 1312 - 1315, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'Artery'

Downloads: 0

Research Paper, Medical Science, India, Volume 10 Issue 7, July 2021

Pages: 500 - 502

A Comparative Study on Maternal Renal Artery Sonographic Findings with Doppler in Women with Hypertensive Disorders of Pregnancy

Dr. Aparna M. | Dr. Manju Sharma | Dr. Minal Yadav | Dr. Sarita Choudhary

Share this Article

Downloads: 0

Research Paper, Medical Science, India, Volume 11 Issue 2, February 2022

Pages: 1109 - 1115

Breathless: Cardiac Output and Congestive Heart Failure Case Review

Dr Jerry Mathew [2] | Dr Ashish Nair [7]

Share this Article


Top