Research Paper | Pharmaceutical Science | Indonesia | Volume 7 Issue 7, July 2018
Observation of Polymorphic Transition of Efavirenz during Heating by Raman Spectroscopy
Yoga Windhu Wardhana | Sundani N. Soewandhi | Veinardi Suendo
Abstract: Efavirenz as an anti-HIV type 1 drug has a lot of polymorph forms. The references reported it had 23 different polymorph forms include amorphous. But the only form I used in pharmaceutical market widespread which known as a stable form with poor solubility properties. Common knowledge that besides a stable form there is a meta-stable form which has more benefit in solubility. One of the meta-stable forms aim to study in this research was the form which result from methanol recrystallization. Characterization of form was slightly different both in diffractogram patterns from XRPD (X-ray Powdered Diffractometry) and the thermogram from DSC (Differential Scanning Calorimetry) comparing with a patent. Others characterizations were carried out such as Infrared (IR) vibration spectrums with IR absorption (Fourier Transform IR) and IR scattering (Raman Spectroscopy) to described polymorph functional groups response. To re-examined the polymorphic transition information from DSC the in-situ temperature dependent of Raman spectroscopy was conducted. There has only a little temperature shifting, from the thermogram the polymorphic transition of form taken place in the range 108.4110.4oC, but from Raman spectral information happen in 100115oC.
Keywords: Efavirenz, Polymorphic transition, Polymorph
Edition: Volume 7 Issue 7, July 2018,
Pages: 724 - 727
How to Cite this Article?
Yoga Windhu Wardhana, Sundani N. Soewandhi, Veinardi Suendo, "Observation of Polymorphic Transition of Efavirenz during Heating by Raman Spectroscopy", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART201941, Volume 7 Issue 7, July 2018, 724 - 727, #ijsrnet
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