International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 236

Research Paper | Biomedical Sciences | India | Volume 8 Issue 1, January 2019


Study of Serum Endothelin - 1 Variation in Sickle Cell Disease

Chandrakant G. Kamble | Dr. Neeraja Mallik | Dr. P.J.Hisalkar | Dr. Jagdish. D. Powar | Dr. Santosh E.Bidwe | Dr. Bhausaheb V. Jagdale | Dr. Shekhar B. Padhyegurjar


Abstract: BACKGROUND: Hb level decreased and Serum Endothelin-1 (ET-) level have been observed increased in sickle cell disease. The biological mechanism of synthesis and regulation of the Endothelin-1 (ET-) will be clear. The aim of the research study is to provide an overview of the Hb, CBC count, and Sr. Endothelin-1 level changes and its significance in sickle cell disease. METHODS: Hematological values Complete blood count (CBC) was measured on fully Automatic blood cell counter hematology analyzer (Coulter LH 780), and HmX Hematology Analyzer with Autoloader. But in this study, we have concentrated on the variables like, Haemoglobin - (Hb), WBC, RBC, PCV and MCV count. All the values were compared to the reference values. The ET-1 was determined by using enzyme-immunoassay (ELISA kit) method, specifically designed for direct measurement of plasma ET-1. The sensitivity of the assay is 0.5pg/ml, and the cross-sensitivity of the antibodies used is reported to be < 1 % with big ET-1. RESULTS: The study showed that, the significant variations in CBC parameters were observed. The White Blood Cells counts (WBC), and Sr. ET-1levels were significantly increased. But the other indices like, Red Blood Cells (RBCs), PCV, and MCV were found significantly decreased with the controls in SCD. P 0.05was considered to be statistically significant. CONCLUSION: The study concluded that, there is an extremely significant difference between mean Serum Hb, CBC and Endothelin-1 (ET-) levels in cases and healthy controls. So the Hb, CBC count and Serum Endothelin-1 level can be used as a clinical bio-marker for the diagnosis of Sickle Cell Disease.


Keywords: Sickle Cell Disease, blood Hb, CBC count, Sr Endothelin-1, bio-marker for the diagnosis


Edition: Volume 8 Issue 1, January 2019,


Pages: 99 - 103

Study of Serum Endothelin - 1 Variation in Sickle Cell Disease


How to Cite this Article?

Chandrakant G. Kamble, Dr. Neeraja Mallik, Dr. P.J.Hisalkar, Dr. Jagdish. D. Powar, Dr. Santosh E.Bidwe, Dr. Bhausaheb V. Jagdale, Dr. Shekhar B. Padhyegurjar, "Study of Serum Endothelin - 1 Variation in Sickle Cell Disease", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20194026, Volume 8 Issue 1, January 2019, 99 - 103, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'Cell'

Downloads: 0

Research Paper, Biomedical Sciences, Congo, Volume 10 Issue 8, August 2021

Pages: 645 - 648

Evolutionary Profile of Drepanocytic Patients Followed at the National Drepanocytosis Reference Centre (CNRDr) Congo Brazzaville

Edwige Paola Chancelle LOUANGA NANITELAMIO [2] | Serge Oscar MOKONO [2] | Chaldam Jesp?re MBANI | Olivia Galiba Atipo - Tsiba | Fabien Roch NIAMA [3] | Etienne MOKONDJIMOBE [4] | Donatien MOUKASSA [6] | Ange Antoine ABENA [4] | Alexis ELIRA DOKEKIAS [2]

Share this Article

Downloads: 0

Research Paper, Biomedical Sciences, Indonesia, Volume 10 Issue 8, August 2021

Pages: 852 - 856

Administration of Myrmecodia pendans Ethanol Extract Cream Prevented Elevation of Keratinocyte Apoptosis and Number of Macrophages in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B (UVB)

Diana Utami | Wimpie Pangkahila [21] | I Gusti Made Aman [5]

Share this Article


Top