International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




Downloads: 120 | Views: 130

Research Paper | Pharmaceutical Science | Iraq | Volume 7 Issue 11, November 2018


Design, Synthesis and Evaluation of New Diclofenac Derivative More Selective COX2 Inhibitor

Yahya S. Yaseen | Muthana S. Farhan | Ammar A. Fadhil | Maysam A. Hussein | Nada N. AL-Shawi


Abstract: New series of 2-Azetidinone (I-IV) were synthesized, the structure of these new derivatives were confirmed using spectral methods starting from diclofenac sodium. We prepared diclofenac acid by using hydrochloric acid, then converted to amide ester by using thionyl chloride, then converted to hydrazide by using hydrazine hydrate 99.5 %, then a Schiff bases were synthesized using different aromatic aldehydes in ethanol, and the final compounds were obtained by cyclocondensation using chloroacetylechloride. The synthesis of the designed compounds has been successfully achieved. Purity and characterization were confirmed by determination of physical properties (melting points & Rf values), FT-IR spectroscopy and CHN analysis.


Keywords: Diclofenac, Schiff base, 2-Azetidinone, antibacterial activity, aldehyde


Edition: Volume 7 Issue 11, November 2018,


Pages: 1394 - 1401


How to Download this Article?

Type Your Email Address below to Download the Article PDF


How to Cite this Article?

Yahya S. Yaseen, Muthana S. Farhan, Ammar A. Fadhil, Maysam A. Hussein, Nada N. AL-Shawi, "Design, Synthesis and Evaluation of New Diclofenac Derivative More Selective COX2 Inhibitor", International Journal of Science and Research (IJSR), Volume 7 Issue 11, November 2018, pp. 1394-1401, https://www.ijsr.net/get_abstract.php?paper_id=ART20192460



Similar Articles with Keyword 'antibacterial activity'

Downloads: 154 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 5, May 2018

Pages: 8 - 12

Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 1, 2-DI (PYRIDINE-4-YL) Hydrazine

Mythili A [3] | Dr. Vijayabaskaran M [2] | Dr. Yogesh D B [2]

Share this Article

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 12, December 2021

Pages: 1301 - 1309

Design and Development of Quercetin Loaded Silver Nanoparticles for Antibacterial Activity

Ritu Sharma [2] | Dr. Dinesh Kaushik | Devender Chauhan

Share this Article



Top