Research Paper | Pharmaceutical Science | India | Volume 7 Issue 10, October 2018
Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6
Devi Velmurugan
Chemometric methods are the development of quantitative structure activity relationships or the Evaluation of analyticalchemical data. The data flood generated by modern analytical instrumentation is one reason, which analytical chemists in particular develop for applications of Chemometric methods. In this study, chemometric assisted UV spectrophotometric method was developed and validated for estimation of Vitamins B1, B2 & B6. It involves absorbance measurement at 264nm max of Thiamine Hydrochloride, 223 nm max of Riboflavin and 219nm max of Pyridoxine in Double distilled water. Linearity was obtained in the range of 2 10 g/ ml for the three drugs with correlation coefficient 0.9990 for three vitamins. The methods were validated as per International Conference on Harmonization Q2 (R1) (ICH) guidelines. These methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation.
Keywords: Vitamins B1, B2 & B6, UV spectroscopy, chemometric method, ICH guidelines
Edition: Volume 7 Issue 10, October 2018
Pages: 147 - 151
How to Cite this Article?
Devi Velmurugan, "Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20191636, Volume 7 Issue 10, October 2018, 147 - 151
150 PDF Views | 80 PDF Downloads
Similar Articles with Keyword 'UV spectroscopy'
Research Paper, Pharmaceutical Science, India, Volume 7 Issue 9, September 2018
Pages: 403 - 406Stress Degradation Studies of Hydrochlorothiazide and Development of Validated Method by UV Spectroscopy
Devi.V, Sekar.V
Research Paper, Pharmaceutical Science, India, Volume 9 Issue 3, March 2020
Pages: 1475 - 1482Development and Validation of UV-Vis Spectroscopy Method for the Determination of Ivabradine Hydrochloride and Metoprolol Succinate in Tablet Dosage Form
S. L Kore, Dr. T. M. Kalyankar
Research Paper, Pharmaceutical Science, India, Volume 6 Issue 4, April 2017
Pages: 2463 - 2466Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Tenoxicam in Bulk and Pharmaceutical Dosage Forms
Vilas Karbhari, Warad Tanuja
Research Paper, Pharmaceutical Science, India, Volume 7 Issue 10, October 2018
Pages: 147 - 151Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6
Devi Velmurugan
Similar Articles with Keyword 'ICH guidelines'
Research Paper, Pharmaceutical Science, India, Volume 7 Issue 9, September 2018
Pages: 403 - 406Stress Degradation Studies of Hydrochlorothiazide and Development of Validated Method by UV Spectroscopy
Devi.V, Sekar.V
Research Paper, Pharmaceutical Science, India, Volume 8 Issue 11, November 2019
Pages: 767 - 773Stability Indicating Validated RP-HPLC Method Development for Simultaneous Estimation of Benidipine Hydrochloride and Telmisartan from Pharmaceutical Dosage Form
Varsha Chandgude, G. K. Dyade, R. B. Jadhav
Research Paper, Pharmaceutical Science, India, Volume 9 Issue 3, March 2020
Pages: 1475 - 1482Development and Validation of UV-Vis Spectroscopy Method for the Determination of Ivabradine Hydrochloride and Metoprolol Succinate in Tablet Dosage Form
S. L Kore, Dr. T. M. Kalyankar
Research Paper, Pharmaceutical Science, India, Volume 7 Issue 1, January 2018
Pages: 634 - 637Validated Spectrophotometric Method Development for Strontium Ranelate from Newly Developed Floating Tablet Formulation
Dhanashree S Chavan, Sachin A Pishawikar, Harinath N. More, Suresh G. Killedar
Research Paper, Pharmaceutical Science, India, Volume 7 Issue 5, May 2018
Pages: 8 - 12Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 1, 2-DI (PYRIDINE-4-YL) Hydrazine
Mythili A, Dr. Vijayabaskaran M, Dr. Yogesh D B