International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Pharmaceutical Science | India | Volume 7 Issue 10, October 2018

Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6

Devi Velmurugan

Chemometric methods are the development of quantitative structure activity relationships or the Evaluation of analyticalchemical data. The data flood generated by modern analytical instrumentation is one reason, which analytical chemists in particular develop for applications of Chemometric methods. In this study, chemometric assisted UV spectrophotometric method was developed and validated for estimation of Vitamins B1, B2 & B6. It involves absorbance measurement at 264nm max of Thiamine Hydrochloride, 223 nm max of Riboflavin and 219nm max of Pyridoxine in Double distilled water. Linearity was obtained in the range of 2 10 g/ ml for the three drugs with correlation coefficient 0.9990 for three vitamins. The methods were validated as per International Conference on Harmonization Q2 (R1) (ICH) guidelines. These methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation.

Keywords: Vitamins B1, B2 & B6, UV spectroscopy, chemometric method, ICH guidelines

Edition: Volume 7 Issue 10, October 2018

Pages: 147 - 151


How to Cite this Article?

Devi Velmurugan, "Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20191636, Volume 7 Issue 10, October 2018, 147 - 151

150 PDF Views | 80 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'UV spectroscopy'

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 9, September 2018

Pages: 403 - 406

Stress Degradation Studies of Hydrochlorothiazide and Development of Validated Method by UV Spectroscopy

Devi.V, Sekar.V

Share this article

Research Paper, Pharmaceutical Science, India, Volume 9 Issue 3, March 2020

Pages: 1475 - 1482

Development and Validation of UV-Vis Spectroscopy Method for the Determination of Ivabradine Hydrochloride and Metoprolol Succinate in Tablet Dosage Form

S. L Kore, Dr. T. M. Kalyankar

Share this article

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 4, April 2017

Pages: 2463 - 2466

Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Tenoxicam in Bulk and Pharmaceutical Dosage Forms

Vilas Karbhari, Warad Tanuja

Share this article

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 10, October 2018

Pages: 147 - 151

Formulation, Method Development of Chemometric Assisted UV Spectrophotometric Method for the Estimation of Vitamins B1, B2 & B6

Devi Velmurugan

Share this article



Similar Articles with Keyword 'ICH guidelines'

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 9, September 2018

Pages: 403 - 406

Stress Degradation Studies of Hydrochlorothiazide and Development of Validated Method by UV Spectroscopy

Devi.V, Sekar.V

Share this article

Research Paper, Pharmaceutical Science, India, Volume 8 Issue 11, November 2019

Pages: 767 - 773

Stability Indicating Validated RP-HPLC Method Development for Simultaneous Estimation of Benidipine Hydrochloride and Telmisartan from Pharmaceutical Dosage Form

Varsha Chandgude, G. K. Dyade, R. B. Jadhav

Share this article

Research Paper, Pharmaceutical Science, India, Volume 9 Issue 3, March 2020

Pages: 1475 - 1482

Development and Validation of UV-Vis Spectroscopy Method for the Determination of Ivabradine Hydrochloride and Metoprolol Succinate in Tablet Dosage Form

S. L Kore, Dr. T. M. Kalyankar

Share this article

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 1, January 2018

Pages: 634 - 637

Validated Spectrophotometric Method Development for Strontium Ranelate from Newly Developed Floating Tablet Formulation

Dhanashree S Chavan, Sachin A Pishawikar, Harinath N. More, Suresh G. Killedar

Share this article

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 5, May 2018

Pages: 8 - 12

Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 1, 2-DI (PYRIDINE-4-YL) Hydrazine

Mythili A, Dr. Vijayabaskaran M, Dr. Yogesh D B

Share this article
Top