Research Paper | Chemical Sciences | Iraq | Volume 7 Issue 9, September 2018
Synthesis of Some new Formazan Derivatives Derived from the Coumarin and Study There Biological Activity
Ghaith K. Ibrahim | Khalid A. Albadrany 
Abstract: This study includes preparing a number of compounds from coumarin, which is like a nucleus for preparing many heterocyclic compounds such as Formazan. As in the following steps. preparing of 7-hydroxy-4-methyl coumarin (G1) of the resorcinol reaction with ethyl aceto ascetate with drops of sulfonic acid, preparing of ethyl 2- ( (4-methyl-2-oxo-2H-chromen-7-yl) oxy) acetate (G2) of a compound reaction (G1) with ethyl chloro acetate with potassium carbonate, preparing of 2- ( (4-methyl-2-oxo-2H-chromen-7-yl) oxy) aceto hydrazide (G3) a compound reaction (G2) with aqueous hydrazine, preparing of (E) -N- (sub. benzylidene) -2- (4-methyl-2-oxo-2H-chromen-7-yl) oxy) acetohydrazide (G4-G10) of a compound reaction (G3) with aldehyde substitutes, preparing of (E, Z) -#- (4-sub. phenyl) -1- (sub. phenyl) -5- (2- ( (4-methyl-2-oxo-2H-chromen-7yl) 0xy) acetyl) farmazan (G11-G24) of a compound reaction (G4-G10) (some Schiff base prepared) with sodium nitrite and -3-amino aceto phenol or -4-amino aceto phenol, The effect of some prepared compounds have been studied on the growth of two types bacterial isolates which are known of their resistance to anti-biotic ( Gr-ve) which is Psedudomonos aeruginosa) and ( GR+ve) which are the Staphylococcus aureus. The anti-biotic Amoxilicine and Ampicillin have been used as samples to control some prepared compounds, and some of the compounds showed good inhabitation activity against the used bacteria.
Keywords: coumarin, Formazan, Schiff bases, Amoxilicine, Ampicillin
Edition: Volume 7 Issue 9, September 2018,
Pages: 822 - 827
How to Cite this Article?
Ghaith K. Ibrahim, Khalid A. Albadrany, "Synthesis of Some new Formazan Derivatives Derived from the Coumarin and Study There Biological Activity", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20191291, Volume 7 Issue 9, September 2018, 822 - 827, #ijsrnet
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