International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 144

Research Paper | Chemistry | Iraq | Volume 7 Issue 3, March 2018


Synthesis of Some New Nucleoside Analogues from Theobromine via Schiff Base

Thanaa M. Al-Mouamin, Sumaya J. Abid


Abstract: Of the approximately 40 antiviral drugs formally approved for use, half of them are nucleoside or nucleotide analogues. So new derivatives of nucleoside analogues were obtained from the work that was conducted in this research. Firstly, the reaction of theobromine was reacted with sodium hydride in DMF at (0 C) to give it & #039, s salt, then the produced salt was reacted with chloroacetyl chloride to produce 1- (chloro acetyl) theobromine [3]. Thereafter, compound [3] was reacted with hydrazine hydrate to give 1- (1-acetohydrazide) theobromine [4] then reacted with a different substitution of an aromatic aldehyde in absolute ethanol to give Schiff & #039, s bases derivatives [5-12]. The reaction of compounds [5-12] with 1, 23, 4-Di-O-isopropylidene- - D- galactopyranosyl bromide [2] forming blocked nucleoside analogues [13-20]. Deblocking of these nucleoside using in 50 % aqueous acetic acid to give the free nucleoside [21-28]. The new prepared compounds were identified by [FTIR, 1H-NMR and 13C-NMR] and their physical properties were measured. Furthermore, we have evaluated the effect of some prepared compounds on some bacterial and fungal strains.


Keywords: Theobromine, Schiff base, anti-microbial


Edition: Volume 7 Issue 3, March 2018,


Pages: 58 - 66


How to Cite this Article?

Thanaa M. Al-Mouamin, Sumaya J. Abid, "Synthesis of Some New Nucleoside Analogues from Theobromine via Schiff Base", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART2018402, Volume 7 Issue 3, March 2018, 58 - 66

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Schiff base'

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, Iraq, Volume 10 Issue 11, November 2021

Pages: 1017 - 1021

Synthesis, Characterization, Thermal Analysis, and Antibacterial Activity of New Tetradentate Ligands and their Complexes

Basher J. Kadhim, Jasim Alshawi, Tahseen Alslaim

Share this Article

Downloads: 5

Research Paper, Chemistry, Nigeria, Volume 10 Issue 8, August 2021

Pages: 949 - 961

Chemical Synthesis and Microbial Evaluation of Iron (II) and Cobalt (II) Complexes of Schiff Base Dervived from ?-Hydroxynapthalene-1-Carbaldehyde Using 2-Aminoaniline and 2-Hydroxyaniline as the Aniline Di-Substituents

Ezenweke Linus Obi, Ojiako Eugenia Nonye, Esonwune Anacletus Anayochukwu, Olugbue Victor U.

Share this Article

Similar Articles with Keyword 'antimicrobial'

Downloads: 124

Research Paper, Chemistry, United Kingdom, Volume 4 Issue 1, January 2015

Pages: 1527 - 1529

Antibacterial Studies of Leucine Complexes of Fe (III) and Cu (II)

K. Asemave, B. A. Anhwange, T. J. Anom

Share this Article

Downloads: 5 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 10 Issue 4, April 2021

Pages: 905 - 908

An Efficient Synthesis for Novel 2, 3-Disubstituted -4-Thiazolidones and Antimicrobial Evaluation

Kishor Huge, Vasant Gurav

Share this Article
Top