A Study of Acute Inflammatory Markers and Serum Lactate Dehydrogenase among Snake Bite Patient in a Tertiary Care Hospital
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Medicine Science | India | Volume 7 Issue 2, February 2018

A Study of Acute Inflammatory Markers and Serum Lactate Dehydrogenase among Snake Bite Patient in a Tertiary Care Hospital

Dr. Sriharsha Kulkarni, Dr Sreedevi T

BACKGROUND AND OBJECTIVES Most of the snake bites occur in developing countries with temperate and tropical climates in which populations subsist on agriculture and fishing. Snake bite, either hemotoxic, neurotoxic, cytotoxic or a combination of these are considered as a grave medical emergency1. Snake venom is believed to act as an acute phase reactants & releasing inflammatory mediators such as IL-6 and 8. IL-6 is believed to act on the liver increasing the production of acute phase reactants2. The phospholipase an important component of snake venom is thought to produce haemolysis. Serum LDH levels have been found to correlate well with the severity of envenomation. To study the role and analyse the relationship between acute inflammatory markers and serum LDH in cases of snake bite envenomation and helpful in predicting the early prognosis in snake bite patient. METHODS 50 patients with history of snake bite who were admitted in SSIMS&RC Devanagere, during the period September-2015 to September-2017, with clinical evidence of snake bite after taking into account of inclusion and exclusion criterias. All the patients worked up for routine and specific laboratory investigations. OBSERVATION AND RESULTS Most of our patients were presented with features suggestive of hemotoxic envenomation. Elevated acute inflammatory markers was seen in patients with severe grade of envenomation in which required more than 30 vials of ASV. A statistically significant correlation was found between acute inflammatory markers and Serum LDH (p value 0.001) with the grade of envenomation and outcome of the snake bite victims. CONCLUSION Hemotoxic snake bites with features compatible with moderate envenomation were found most commonly in our study population. Acute inflammatory markers and Serum LDH levels help to differentiate between patients with severe envenomation and other grades of envenomation. The above markers also helps in predicting the early prognosis and outcome in the snake bite victims.

Keywords: Serum CRP, Ferritin, Serum LDH, Fibrinogen, ESR

Edition: Volume 7 Issue 2, February 2018

Pages: 1405 - 1409

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Dr. Sriharsha Kulkarni, Dr Sreedevi T, "A Study of Acute Inflammatory Markers and Serum Lactate Dehydrogenase among Snake Bite Patient in a Tertiary Care Hospital", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART2018388, Volume 7 Issue 2, February 2018, 1405 - 1409

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