International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Research Paper | Medical Surgical | Spain | Volume 7 Issue 5, May 2018


Enhanced Removal of Heavy Metals and SOD-1 Rises by Chronic Nutraceutical Supplementation in Patients with Long-Term Dental Amalgams

Jose Joaquin Merino [4] | Jose Maria Parmigiani-Izquierdo [3] | Maria Eugenia Cabana-Munoz [3]


Abstract: Introduction The accumulations of heavy metal/s in human body is a serious health problem. Aim we have evaluated whether 80 days of chronic supplementation with several nutraceuticals (selenium, silimarine, L-Glutamine, Cordiceps among others) could prevent heavy metal accumulation in patients with long-term amalgams (n=17, average 5 dental amalgams for 15 years). These selected patients have long-term dental amalgams for at least 10 years (average 15 years) and they had five amalgams (average). In addition, we have evaluated whether 80 days of nutraceutical supplementation (day 80) may prevent certain oligoelement deficits found among patients with long-term dental amalgams as compare their basal levels (day zero (d0 controls before any supplementation). Material and methods we have compared a plethora of hairs heavy metals/oligoelements after 80 days of supplementation (n=17, day 80 (d80), g/g hair by ICP-MS) as compare their basal levels before any supplementation (day zero, n=17). The mean heavy metals/oligoelements +-S. E. M are shown as control percentage before any supplementation (day 0. Controls are 100 % of value) Results The chronic supplementation with nutraceutics for 80 consecutive days rise salivary SOD-1 and GSH (reduced form) levels and also prevented heavy metal accumulation since levels of Hg++, Ag, Sn, Cu++, Al, Pb) were significantly reduced in patients with long-term dental amalgams (average 5) as compare their basal levels (before any supplementation at day 0). In addition, Sodium (Na+) levels decreased, Borum and Lithium rise after 80 days of supplementation as compare their respective basal levels. Conclusion These salivary GSH and SOD-1 activity rise could enhance heavy metal detoxification after 80 days of supplementation with nutraceuticals (silimarine, selenium (Se), L-Glutamine, Cordiceps) in these patients. This is the first clinical study in which phytonaturals enhance heavy metal/s removal and also rise endogenous antioxidante systems among patients with long-term dental amalgams.


Keywords: Glutathione GSH, SOD-1, oxidative stress, antioxidants, heavy metals, oligoelements, Selenium, neurotoxicity, dental clinic, odontology


Edition: Volume 7 Issue 5, May 2018,


Pages: 1067 - 1077

Enhanced Removal of Heavy Metals and SOD-1 Rises by Chronic Nutraceutical Supplementation in Patients with Long-Term Dental Amalgams


How to Cite this Article?

Jose Joaquin Merino, Jose Maria Parmigiani-Izquierdo, Maria Eugenia Cabana-Munoz, "Enhanced Removal of Heavy Metals and SOD-1 Rises by Chronic Nutraceutical Supplementation in Patients with Long-Term Dental Amalgams", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20182215, Volume 7 Issue 5, May 2018, 1067 - 1077, #ijsrnet

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