Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 4-Amino Pyridine N-Oxide
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



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Research Paper | Pharmaceutical Science | India | Volume 7 Issue 5, May 2018

Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 4-Amino Pyridine N-Oxide

Mythili A, Dr. Vijayabaskaran M, Dr. Yogesh D B

Objective 4-Aminopyridines and its impurities are important intermediates for chemicals, pharmaceuticals and agrochemical industry, antineoplastic, anticoagulant, anti-inflammatory [1]. Dalfampridine used for the treatment of multiple sclerosis so, the drug availability in the finished dosage form is very important. In the present study we evaluated antibacterial activity of synthesized 4- amino pyridine n- oxide by using agar cup method. Methods The serially diluted antibacterial test solution three doses of synthesized 4- amino pyridine n- oxide (50g/ml, 75g/ml and 100g/ml) were added in the cups and all the plates stood incubated for 24 hours at 370C. The zone of inhibition was measured and compared with gentamycin as a positive control. Results The synthesized 4- amino pyridine n- oxide (100g/ml) was found to be effective and it exhibited substantial antibacterial activity against its direction of Escherichia-coli Pseudomonas-aeruginosa Bacillus-subtilis Staphylococcus-aureus which activity is lesser than standard. Whereas100g/ml dose showed higher anti bacterial activity with more zone of inhibition than 75g/ml and 50g/ml dose. Conclusions The results proposed 100g/ml of synthesized 4- amino pyridine n- oxide showed significant antibacterial activity but less activity than standard drug gentamycin.

Keywords: Dalfampridine, Genotoxic impurities, N Oxidation, Nitration, Reduction, LC-MS, 1H NMR, Melting point, Anti bacterial activity

Edition: Volume 7 Issue 5, May 2018

Pages: 13 - 16

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Mythili A, Dr. Vijayabaskaran M, Dr. Yogesh D B, "Synthesis, Characterisation and its Anti Bacterial Activity of Dalfampridine Genotoxic Impurity 4-Amino Pyridine N-Oxide", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20182027, Volume 7 Issue 5, May 2018, 13 - 16

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