Synthesis and Antibacterial Activity Screening of New Trimethoprim Derivatives Containing Bis Cyclic Imides
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

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Research Paper | Chemistry | Iraq | Volume 7 Issue 5, May 2018

Synthesis and Antibacterial Activity Screening of New Trimethoprim Derivatives Containing Bis Cyclic Imides

Baraa Hassan Latief, Ahlam Marouf Al-Azzawi

The present work involved synthesis of new trimethoprim derivatives containing bis cyclic imides. Synthesis of the new derivatives containing maleimide, citraconimide, succinimide, phthalimide and tetrachloro phthalimide cycles was performed by reaction of trimethoprim with cyclic anhydrides producing bisamic acids which inturn were dehydrated to the corresponding bis cyclic imides by fusion method, while synthesis of trimethoprim linked to bis 1, 8- naphthalimides was made by direct fusion of trimethoprim with 1, 8- naphthalic anhydride in glacial acetic acid. The new derivatives were characterized on the basis of their FTIR, 1HNMR and 13C-NMR spectra and the results of their antibacterial activity screening showed that they exhibit good antibacterial activity

Keywords: Trimethoprim, bisamic acids, biscyclicimide

Edition: Volume 7 Issue 5, May 2018

Pages: 82 - 85

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How to Cite this Article?

Baraa Hassan Latief, Ahlam Marouf Al-Azzawi, "Synthesis and Antibacterial Activity Screening of New Trimethoprim Derivatives Containing Bis Cyclic Imides", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20181991, Volume 7 Issue 5, May 2018, 82 - 85

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Downloads: 127 | Monthly Hits: ⮙7

Research Paper, Chemistry, Iraq, Volume 7 Issue 5, May 2018

Pages: 82 - 85

Synthesis and Antibacterial Activity Screening of New Trimethoprim Derivatives Containing Bis Cyclic Imides

Baraa Hassan Latief, Ahlam Marouf Al-Azzawi

Share this Article



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