International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064

Comparative Studies | Medicine Science | India | Volume 7 Issue 2, February 2018

High Dose Corticosteroids - A Boon or Bane in Dengue Fever with Thrombocytopenia: A Case Control Study

Dr Sachin Nayak Sujir, Dr Narendra SS, Dr Ashray V, Dr Vijay Kumar

Dengue infection is an important public health problem globally infecting about 50100 million individuals every year. The increased peripheral destruction of the antibody coated platelets has been strongly suspected as the possible mechanism for thrombocytopenia in Dengue Fever. Corticosteroids are highly effective anti-inflammatory agents, frequently employed as adjunctive therapy in disease states where the host immune response is thought to contribute significantly to disease pathogenesis This was a case control study about the effect of high dose corticosteroids on platelet count in dengue fever patients. The study was conducted on 80 patients with dengue NS1+ve with platelet count less than 1, 00, 000 cu/mm. The study group received intravenous dexamethasone 16 mg initially, followed by 8 mg every 8 hours, thereafter for 4days. The control Group received only IV fluids and antipyretics whenever necessary. From this study we found that there was no significant difference in trends of increasing platelet counts between the two groups. The hospital stay was similar in both the groups, without any mortality and none of them developed shock or were admitted to intensive care during the study period of five days. In view of these observations, we conclude that the empirical use of steroids may be avoided in dengue fever with thrombocytopenia as high dose dexamethasone lacks efficacy in increasing the platelet count in thrombocytopenic dengue patients. The drawback of our study was, it was not a double blind placebo controlled trial and there were less number of subjects and cases of DHF and DSS were not included

Keywords: Dengue fever, Thrombocytopenia, Corticosteroids, platelet count

Edition: Volume 7 Issue 2, February 2018

Pages: 157 - 160


How to Cite this Article?

Dr Sachin Nayak Sujir, Dr Narendra SS, Dr Ashray V, Dr Vijay Kumar, "High Dose Corticosteroids - A Boon or Bane in Dengue Fever with Thrombocytopenia: A Case Control Study", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20179914, Volume 7 Issue 2, February 2018, 157 - 160

30 PDF Views | 31 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Dengue fever'

Case Studies, Medicine Science, India, Volume 5 Issue 4, April 2016

Pages: 1727 - 1729

Globe Rupture ? A Rare Ocular Manifestation of Dengue Fever in Convalescent Phase

Dr. AG Kulkarni, Dr. Neha Athale, Dr. Kulin Sheth, Dr. Amit Rathi, Dr. Vikramaditya Shinde, Dr. Shridhar Deshmukh, Dr. Pavan Yadav

Share this article

Case Studies, Medicine Science, India, Volume 3 Issue 11, November 2014

Pages: 2251 - 2253

Dengue Encephalitis with Acute Intracerebral Infarction and Facial Palsy; A Rare Presentation

Jitendra Singh, Anju Dinkar, Kamlesh Kumar Gupta, Anurag Kumar Singh, Saurabh Kumar, Dandu Himanshu

Share this article

Case Studies, Medicine Science, India, Volume 5 Issue 10, October 2016

Pages: 1978 - 1981

Dengue: A Clinicopathological Correlation

Dr Sandeep Rai, Dr Aadijay Bhatia, Dr Tasneem Bharmal, Dr Parineeta Samant, Dr Madhur Rai

Share this article

Case Studies, Medicine Science, Sri Lanka, Volume 7 Issue 2, February 2018

Pages: 1641 - 1643

Dengue Encephalitis and Encephalopathy are Different Entity - Case Study

Dr. M. Umakanth

Share this article

Research Paper, Medicine Science, India, Volume 5 Issue 4, April 2016

Pages: 2272 - 2275

A Study on Clinical Presentation of Dengue Fever in Children

Dr. Anjali S Raj, Dr. Sucheta Munshi, Dr. Bela H Shah

Share this article

Similar Articles with Keyword 'Thrombocytopenia'

Case Studies, Medicine Science, India, Volume 3 Issue 11, November 2014

Pages: 1899 - 1900

Enteric Fever Presenting As Diarrhoea and Thrombocytopenia: A Case Report

Dr. S. Rajendra Prasad, Dr. Subash Chandra B J, Dr. Bhanukumar M, Dr. M. G. Mahesh, Dr. Ashok P, Dr. Abhithraj K

Share this article

Research Paper, Medicine Science, India, Volume 4 Issue 10, October 2015

Pages: 1186 - 1189

Etiological Profile of Pancytopenia in a Tertiary Care Hospital of Kashmir Valley

Tariq Abdullah Mir, Mudasir Hamid Bhat, Akhter Amin Raina

Share this article

Case Studies, Medicine Science, India, Volume 5 Issue 10, October 2016

Pages: 1978 - 1981

Dengue: A Clinicopathological Correlation

Dr Sandeep Rai, Dr Aadijay Bhatia, Dr Tasneem Bharmal, Dr Parineeta Samant, Dr Madhur Rai

Share this article

Research Paper, Medicine Science, India, Volume 5 Issue 10, October 2016

Pages: 1198 - 1199

A Study of Papaya Extract in the treatment of Low Platelet Count

Dr Prashanth Kumar

Share this article

Research Paper, Medicine Science, India, Volume 5 Issue 2, February 2016

Pages: 530 - 533

Clinical Outcomes of Patients Presenting As Fever with Thrombocytopenia in Marathwada Region

Nikalje Anand, Talib S.H., Pagar Bhushan, Patil Sumit, Patil Piyush, Kurhade Aniket

Share this article

Similar Articles with Keyword 'Corticosteroids'

Research Paper, Medicine Science, Albania, Volume 4 Issue 8, August 2015

Pages: 1909 - 1912

The Treatment of Diabetic Retinopathy

Orgeta Dervishi, Vilma Mema

Share this article

Case Studies, Medicine Science, India, Volume 3 Issue 10, October 2014

Pages: 671 - 674

Rare Presentation of SLE-Convulsion without Stroke before the Appearance of Malar Rash: A Case Study

Dr. Vijaykumar S. Gulwe, Dr. Ajeya N. Ukadgaonkar, Dr. Vishal R. Dalvi, Dr. Sandeep Sanap, Dr. Vajed Mogal

Share this article

Review Papers, Medicine Science, Albania, Volume 3 Issue 10, October 2014

Pages: 1580 - 1584

The HELLP Syndrome: Clinical Issues and Complications. Management and Two Different Profilatic Considerations and Treatments: Heparin vs Dexamethason: A Review

Prof. A. Manaj, E. Bylykbashi, M. Muhametaj M. D., I. V. Bylykbashi

Share this article

Review Papers, Medicine Science, India, Volume 3 Issue 11, November 2014

Pages: 466 - 474

Globalisation of Herbal Drugs: A Bliss and Concern

Jyoti Ahlawat, Nidhi Verma, Anita R. Sehrawat

Share this article

Review Papers, Medicine Science, India, Volume 8 Issue 9, September 2019

Pages: 629 - 633

A Review on Inflammatory Bowel Disease and their Treatment

Mojabir Hussen Ansari, Dr. Sheelpriya R. Walde

Share this article

Similar Articles with Keyword 'platelet count'

Research Paper, Medicine Science, India, Volume 6 Issue 6, June 2017

Pages: 1179 - 1180

A Study of Platelet Indices in PIH

Dr Indira S Bangera

Share this article

Case Studies, Medicine Science, India, Volume 3 Issue 11, November 2014

Pages: 1899 - 1900

Enteric Fever Presenting As Diarrhoea and Thrombocytopenia: A Case Report

Dr. S. Rajendra Prasad, Dr. Subash Chandra B J, Dr. Bhanukumar M, Dr. M. G. Mahesh, Dr. Ashok P, Dr. Abhithraj K

Share this article

Case Studies, Medicine Science, India, Volume 5 Issue 4, April 2016

Pages: 1727 - 1729

Globe Rupture ? A Rare Ocular Manifestation of Dengue Fever in Convalescent Phase

Dr. AG Kulkarni, Dr. Neha Athale, Dr. Kulin Sheth, Dr. Amit Rathi, Dr. Vikramaditya Shinde, Dr. Shridhar Deshmukh, Dr. Pavan Yadav

Share this article

Research Paper, Medicine Science, Saudi Arabia, Volume 5 Issue 11, November 2016

Pages: 1842 - 1845

Assessment of Hypercoagulability (Platelet Count and Indices) in Sudanese Patients with Acute Myeloblastic Leukemia

Hana Salah Taha, Tarig Altayeb Mohammed, Ahmed El-basher Abdlegader, Amar B Elhussein, Mohand Gafar Nabag, IhabHamed Nourein

Share this article

Research Paper, Medicine Science, Albania, Volume 5 Issue 12, December 2016

Pages: 1340 - 1343

Can Biomarkers Predict Liver Cirrhosis in Chronic Hepatitis C?

Stela Taci, Edite Sadiku, Floreta Kurti, Adriana Babameto, Jovan Basho

Share this article

Top