Oxidative Stress Status in Hypertensive Patients on Capoten Treatment
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Dental Science | Iraq | Volume 7 Issue 2, February 2018

Oxidative Stress Status in Hypertensive Patients on Capoten Treatment

Bahaa Noor Madhloom, Ameena Ryhan Diajil

Background hypertension is a condition in which the blood vessels have persistently raised pressure, putting them under increased stress. Oxidative stress is an imbalance between ROS and antioxidant defense mechanisms, causing damage to biological macromolecules and dysregulation of normal metabolism and physiology. Oxidative stress is contributes to the etiology of hypertension in humans. Capoten is an angiotensin-converting enzyme (ACE) inhibitor. Which is responsible for the conversion of angiotensin I to angiotensin II. The aim of this study was to assess the oxidative stress in hypertensive patients on Capoten treatment through the assessment of salivary Malondialdehyde (MDA) and superoxide dismutase (SOD) as a marker of oxidative stress. Material and method 60 individuals were included in this study, divided into two groups, one study group and one control group. The first group composed of 30 hypertensive patients on Capoten antihypertensive agent. The second group (control group) composed of 30 healthy subjects without any systemic disorder and almost healthy oral hygiene. Intraoral examination was done for each individual. Saliva samples were collected in restful and quit circumstances, the salivary flow rate (F/R) was calculated ml per minute. PH of salivary secretion were measured by PH meter. The levels of salivary MDA and SOD were analyzed by using ELISA kit based on the principle of Competitive enzyme immunoassay technique, the concentrations of markers were measured by spectrophotometer at 450nm in a microplate reader. Results salivary MDA was significantly higher in patients groups in relation to control group. Salivary SOD was significantly lower in patient groups in relation to control group. Salivary flow rate and PH was significantly lower in patient groups comparing to control group. Conclusions salivary MDA and SOD can be used as potential marker for monitoring patients with Hypertension.

Keywords: Oxidative stress, hypertension, Capoten, MDA, SOD, Salivary flow rate and PH

Edition: Volume 7 Issue 2, February 2018

Pages: 443 - 449

Share this Article

How to Cite this Article?

Bahaa Noor Madhloom, Ameena Ryhan Diajil, "Oxidative Stress Status in Hypertensive Patients on Capoten Treatment", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20179901, Volume 7 Issue 2, February 2018, 443 - 449

163 PDF Views | 140 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Oxidative stress'

| Weekly Popularity: ⮙3

Review Papers, Dental Science, India, Volume 8 Issue 2, February 2019

Pages: 1288 - 1289

Fighting Stress with Root Canal

Anu Vashisht

Share this Article

| Weekly Popularity: ⮙2

Research Paper, Dental Science, Iraq, Volume 6 Issue 10, October 2017

Pages: 1684 - 1687

Oral findings, Oxidative Stress and Antioxidant Biomarker Assessment in Serum and Saliva of Crohns Patients

Zainab Kh. Abbas; Taghreed F. Zaidan

Share this Article

Research Paper, Dental Science, Iraq, Volume 7 Issue 2, February 2018

Pages: 443 - 449

Oxidative Stress Status in Hypertensive Patients on Capoten Treatment

Bahaa Noor Madhloom, Ameena Ryhan Diajil

Share this Article

Similar Articles with Keyword 'hypertension'

| Weekly Popularity: ⮙6

Research Paper, Dental Science, Saudi Arabia, Volume 7 Issue 4, April 2018

Pages: 1470 - 1477

Threat to Coronary Heart Disease Risk Factors: Preponderance and Behavior Among Al Jouf University Dental Students in Sakaka City, Saudi Arabia

Dr. Farahnaz Muddebihal, Dr. May Osman Hamza Babeker, Dr. Mohammed Anwar Ul Haque Chand

Share this Article

Review Papers, Dental Science, Indonesia, Volume 6 Issue 6, June 2017

Pages: 1478 - 1482

Hypertension in Children: Manifestation and Oral Treatment with Therapeutic Approach

Harun Achmad, Hasanuddin Thahir, Mardiana Adam

Share this Article

| Weekly Popularity: ⮙6

Review Papers, Dental Science, India, Volume 6 Issue 7, July 2017

Pages: 1544 - 1545

Fruit-Eating in Management of Hypertension

R. S. Rakhi Menon

Share this Article

Research Paper, Dental Science, Iraq, Volume 7 Issue 2, February 2018

Pages: 443 - 449

Oxidative Stress Status in Hypertensive Patients on Capoten Treatment

Bahaa Noor Madhloom, Ameena Ryhan Diajil

Share this Article

| Weekly Popularity: ⮙3

Case Studies, Dental Science, Indonesia, Volume 8 Issue 8, August 2019

Pages: 7 - 11

Ludwigs Angina as an Odontogenic Infection: Management and Characteristics of Fifteen Patients

Endang Sjamsudin, Agus Nurwiadh, Seto Adiantoro, Annisa Muharty, R. Nusjirwan

Share this Article

Similar Articles with Keyword 'MDA'

| Weekly Popularity: ⮙2

Research Paper, Dental Science, Iraq, Volume 6 Issue 10, October 2017

Pages: 1684 - 1687

Oral findings, Oxidative Stress and Antioxidant Biomarker Assessment in Serum and Saliva of Crohns Patients

Zainab Kh. Abbas; Taghreed F. Zaidan

Share this Article

| Weekly Popularity: ⮙4

Research Paper, Dental Science, India, Volume 8 Issue 2, February 2019

Pages: 1526 - 1529

Assessment of Dental Anxiety towards Dental Care among Patients Attending Dental Institution in Bengaluru City

Padma K Bhat, Mamatha Murthy, Jayachandra M.Y, Rajkumari Surbala Devi, Sushma S.G

Share this Article

Research Paper, Dental Science, Iraq, Volume 7 Issue 2, February 2018

Pages: 443 - 449

Oxidative Stress Status in Hypertensive Patients on Capoten Treatment

Bahaa Noor Madhloom, Ameena Ryhan Diajil

Share this Article

Similar Articles with Keyword 'SOD'

| Weekly Popularity: ⮙6

Research Paper, Dental Science, Morocco, Volume 7 Issue 8, August 2018

Pages: 1683 - 1684

Effectiveness of the Laser on TMD - Systematic Review

A. Mouhibi, A. Chafii, A. Andoh

Share this Article

| Weekly Popularity: ⮙4

Research Paper, Dental Science, India, Volume 10 Issue 2, February 2021

Pages: 1263 - 1267

Comparative Antimicrobial Efficacy of Chrysopogon Zizanioides and Matricaria Chamomilla along with 5.25% Sodium Hypochlorite and 2% Chlorhexidine against Enterocococcus Faecalis: An In-Vitro Study

Dr. Shashin Shah, Dr. Nidhi Ruparelia, Dr. Vaibhavi Solanki, Dr. Bansri Patel

Share this Article

Research Paper, Dental Science, Iraq, Volume 6 Issue 2, February 2017

Pages: 1962 - 1965

Dissolution of Inorganic Phosphorous Ion from Teeth Treated with Different Concentrations of Aqueous Extract of Nigella Sativa (Black Seed) in Comparison with Sodium Fluoride: An in Vitro Study

Nibal Mohammed Hoobi, Mohammed Ghalib Rzoqi

Share this Article

| Weekly Popularity: ⮙2

Review Papers, Dental Science, Bulgaria, Volume 7 Issue 8, August 2018

Pages: 1558 - 1565

The Ability of Root Canal Cleaning and Shaping Procedures to Initiate Dentinal Radicular Microcracks

Irina Tsenova, Radosveta Vassileva, Emilia Karova

Share this Article

| Weekly Popularity: ⮙4

Survey Paper, Dental Science, Saudi Arabia, Volume 6 Issue 2, February 2017

Pages: 1744 - 1745

Irrigation Trends among Endodontists in Saudi Arabia

Mohammed Waseem, Omar Alhindi, Nail Alanazi, Turki Dahman, Rakan Alsubaity, Abdullah Riyadh

Share this Article
Top