Epilepsy and Autism Comorbidity - Up-To-Date Review
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Downloads: 133 | Weekly Hits: ⮙2 | Monthly Hits: ⮙10

Review Papers | Pediatrics | Albania | Volume 7 Issue 1, January 2018

Epilepsy and Autism Comorbidity - Up-To-Date Review

Aferdita Tako, Aida Bushati

This article aims to present an up-to-date viewpoint regarding epilepsy and autism comorbidity. Extensive research in neurobiology and genetic studies have showed significant proof of a common foundation of genetic factors and pathophysiological pathways in both, epilepsy and autism. We present some clinical implications regarding evidence-based approaches to diagnosis and management in patients with this comorbidity. Methodology The authors have reviewed multiple studies and articles authored by experts and respected scientist in the field up to the year 2015. These consist in genetic, neurobiological, neuropathophysiological, and electroencephalographic studies combined with clinical data. Clinically-oriented results and implications were extracted and used to present practice recommendations with the strongest evidence support. A detailed list of the material used can be found in the reference sector. The correlation between ASD, neurologic dysfunction and epilepsy suggests an underlying encephalopathy presenting with a combination of neurologic abnormalities, including clinical epileptiform activity. The estimated rate of comorbidity varies between 2025 % of the whole spectrum. Several biological pathways appear to be involved in both disease processes, including gene transcription regulation, cellular growth, synaptic channel function, and maintenance of synaptic structure. The American Academy of Neurology and the Child Neurology Society practice parameters state that there is inadequate evidence to recommend an EEG study in all individuals with autism. In the absence of clinical epilepsy, treatment of EEG epileptiform activity with AEDs has not been demonstrated to reverse the symptoms of ASD. epilepsy, autism, co morbidity, Electroencephalography, Fragile X syndrome, tuberous sclerosis complex

Keywords: epilepsy, autism, co morbidity, Electroencephalography, Fragile X syndrome, tuberous sclerosis complex

Edition: Volume 7 Issue 1, January 2018

Pages: 1256 - 1259

Share this Article

How to Cite this Article?

Aferdita Tako, Aida Bushati, "Epilepsy and Autism Comorbidity - Up-To-Date Review", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20179674, Volume 7 Issue 1, January 2018, 1256 - 1259

Enter Your Registered Email Address





Similar Articles with Keyword 'epilepsy'

Downloads: 109 | Weekly Hits: ⮙2 | Monthly Hits: ⮙10

Research Paper, Pediatrics, India, Volume 4 Issue 10, October 2015

Pages: 1224 - 1227

Psychosocial Issues beyond Seizures: A Study of Behavioral Problems in Paediatric Epilepsy Patients

Poorvi C. Agrawal, Anuya V. Chauhan, Gargi H. Pathak

Share this Article

Downloads: 111 | Weekly Hits: ⮙1 | Monthly Hits: ⮙11

Dissertation Chapters, Pediatrics, Albania, Volume 4 Issue 10, October 2015

Pages: 2140 - 2143

Febrile Seizure Preventive Treatment for Recurrences

Artan Haruni, Valentina Tashko

Share this Article

Downloads: 115 | Weekly Hits: ⮙1 | Monthly Hits: ⮙8

Case Studies, Pediatrics, Saudi Arabia, Volume 5 Issue 11, November 2016

Pages: 1255 - 1258

An Unexpected Presentation of Child Abuse Case Report and Review of the Literature

Mosa Y. Hakami, Alaa A. Hakami, Magda A. Khazbak

Share this Article

Downloads: 117 | Weekly Hits: ⮙2 | Monthly Hits: ⮙9

Research Paper, Pediatrics, India, Volume 4 Issue 1, January 2015

Pages: 1963 - 1966

Clinical Profile of Childhood Neuro Cysticercosis

Dr. P. Yashodhara, Dr. B. Elizabeth

Share this Article

Downloads: 119 | Weekly Hits: ⮙2 | Monthly Hits: ⮙9

Case Studies, Pediatrics, Albania, Volume 5 Issue 3, March 2016

Pages: 2131 - 2135

Epilepsy and Epileptic Syndromes Cases Presented at Neuropediatricclinic of ?Mother Theresa? University Hospital Center, Tirana, 2012-2014

Aferdita Tako Kumaraku, Aida Bushati, Agim Gjikopulli, Renald Mecani, Valentina Tashko

Share this Article

Similar Articles with Keyword 'autism'

Downloads: 90 | Weekly Hits: ⮙3 | Monthly Hits: ⮙12

Research Paper, Pediatrics, Egypt, Volume 4 Issue 9, September 2015

Pages: 58 - 66

Meet the Professionals Day; Evaluation of the Autistic Children Caregivers Knowledge, Concerns, and Needs

Eman Ahmed Zaky, Eman Abdel Aziz, Reham Elhossiny, Randa Khalaf, Asmaa Wafik, Sally Ahmed, Walaa Youssef, Shereen Mostafa, Rana Abdel Hakim, Ayaa Hassan

Share this Article

Downloads: 117 | Weekly Hits: ⮙2 | Monthly Hits: ⮙10

Research Paper, Pediatrics, Egypt, Volume 4 Issue 6, June 2015

Pages: 1365 - 1373

Prevalence of Autism Spectrum Disorders in Vitamin D Deficient or Insufficient Rickets

Eman Ahmed Zaky, Eman M Fouda, Eman A Algohary, Eman S Al-Shony

Share this Article

Downloads: 123 | Weekly Hits: ⮙1

Review Papers, Pediatrics, India, Volume 4 Issue 8, August 2015

Pages: 1576 - 1578

Autism in Children: A Literature Review

Dr. Arun Parikh

Share this Article

Downloads: 128 | Weekly Hits: ⮙5 | Monthly Hits: ⮙15

Research Paper, Pediatrics, Egypt, Volume 4 Issue 10, October 2015

Pages: 561 - 570

Phenotypic and Genotypic Profile of an Egyptian Sample of Children with Neurodevelopmental Disorders; Two Case Reports of Microdeletion 22q11.2 Syndrome (DiGeorge/Velocardiofacial Syndrome)

Eman A Zaky, Ezzat Elsobky, Solaf Elsayed, Nardin Botros, Hany Rizk

Share this Article

Downloads: 131 | Weekly Hits: ⮙2 | Monthly Hits: ⮙12

Research Paper, Pediatrics, Indonesia, Volume 5 Issue 5, May 2016

Pages: 325 - 327

Difference of def-t and DMF-T Index of Autism Children and Normal Children

Yetty Herdiyati Nonong, Eka Chemiawan, Prima Abigail Gayatri

Share this Article



Top