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Research Paper | Pediatrics | Indonesia | Volume 7 Issue 1, January 2018

The Therapy Profile of Anti-Epilepsy Drugs in Spastic Cerebral Palsy of Indonesian Subject

Anidar ^[3] | Irawan Mangunatmadja | Setyo Handryastuti | Cissy Rachiana B. Kartasasmita | Tuti Wahmurti A. Sapiie | Nelly Amalia Risan

Abstract: . Background. Generally epilepsy may occur in children as well as patients with cerebral palsy. Epilepsy in children with cerebral palsy is difficult to control, therefore a regular evaluation of treatment response is required. Epilepsy treatment in cerebral palsy pediatric children requires the administration of long-term anti-epilepsy drugs either monotherapy or polytheraphy with a success indicator that patients are seizure-free for more than one year. Objective. To describes anti-epilepsy drug therapy on spastic cerebral palsy. Method. the study started by conducting exploration of research data through medical record study from 125 subjects who experienced spastic cerebral palsy with epilepsy, age range of subjects 1-18 years, then the findings were analyzed descriptively based on character from subject, therapy, free from seizure, and application of medicine anti epilepsy for cerebral palsy epilepsy. Results. The type and comorbidity of spastic cerebral palsy are as follows tetraplegia 52 % (as dominant type), diplegia 28 %, and hemiplegia 20 %. The most frequent epilepsy is general tonic clonic epilepsy as much as 40 %, followed by general tonic epilepsy as much as 30, 4 %, and last is partial complex as much as 11, 2 %. The application of valproic acid (81.6 %) is the most treatment as anti-epilepsy which is administrated through monotherapy application (64 %). The results also showed a seizure-free condition dominated by more than 1 year (13.6 %). Conclusion. The type of tetraplegia as the most dominant form with epilepsy comorbidity, monotherapy therapy is more widely used and seizure free is known to be low.

Keywords: Anti-epilepsy drugs, Epilepsy, Spastic cerebral palsy

Edition: Volume 7 Issue 1, January 2018,

Pages: 997 - 1000

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