Research Paper | Zoology | India | Volume 6 Issue 12, December 2017
Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle
Sushma Sharma, Anupam Pundir
In the era of expanding energy program all over the world, the role of radiation biology has acquired greater relevance and significance in addressing the health issues. In present time, nuclear terrorism and weapons related effects are raising much alarm and concern to public health. Radiation is often used to treat malignant tumours, or in combination with surgery. Ionizing radiation is known to produce deleterious effects on living organisms. Despite the advantage of radiotherapy and improvements in techniques, many patients experience moderate to severe side effects including xerostomia, diarrhea, mucositis, dermatitis, ulceration and fibrosis. Reactive oxygen species (ROS) such as hydroxyl radical (OH), superoxide anion radicals (O2) and hydrogen peroxide (H2O2) were produced as a response to ionizing radiation Mammalian cells are equipped with both enzymatic and non-enzymatic antioxidant mechanisms to minimize cellular damage resulting from interaction between cellular constituents and ROS. Under normal conditions, a delicate balance exists between the generation of ROS and the cellular antioxidant systems. Over production of ROS in both intra and extra-cellular spaces upon exposure of cells to ionizing radiation results in oxidative stress due to the imbalance between pro-oxidants and antioxidants. The objective of the present study was to evaluate the antioxidant enzyme activities (Superoxide dismutase, Catalase and lipid peroxidation ) in biceps muscle of mice. Mice were divided into 4 groups. Study was performed at 7, 14, 21 and 28 days stage. Present study convincingly demonstrated that Adhatoda extract provides protection against free radical damage.
Keywords: Radiation, Antioxidant enzymes, Reactive oxygen species, Superoxide dismutase, Catalase
Edition: Volume 6 Issue 12, December 2017
Pages: 656 - 661
How to Cite this Article?
Sushma Sharma, Anupam Pundir, "Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20178664, Volume 6 Issue 12, December 2017, 656 - 661
147 PDF Views | 127 PDF Downloads
Similar Articles with Keyword 'Radiation'
| Weekly Popularity: ⮙5
Research Paper, Zoology, India, Volume 5 Issue 9, September 2016
Pages: 1216 - 1219Histological Alterations in the Spleen of Gamma-Irradiated Mice Induced by Adhatoda vasica Leaf Extract
Sushma Sharma, Mahender Singh
| Weekly Popularity: ⮙1
Research Paper, Zoology, India, Volume 4 Issue 6, June 2015
Pages: 1995 - 2003Effect of Induced Environmental Stress on the Butterfly, Catopsilia Pomona Pomona Fabricius, 1775
Jayarama Reddy, Nitin Ravikanthachari
| Weekly Popularity: ⮙1
Research Paper, Zoology, India, Volume 6 Issue 12, December 2017
Pages: 656 - 661Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle
Sushma Sharma, Anupam Pundir
Similar Articles with Keyword 'Antioxidant enzymes'
Research Paper, Zoology, India, Volume 4 Issue 9, September 2015
Pages: 881 - 884Antioxidant Activity of Root of Achyranthes Aspera and its Comparison with Melatonin in Recovery of Oxidative Stress
Nisreen Husain, Anil Kumar
| Weekly Popularity: ⮙2
Research Paper, Zoology, India, Volume 6 Issue 5, May 2017
Pages: 1050 - 1056Protective Effect of Vitamin C on Carbon Tetrachloride Administered Toxicity in Lungs of Mice
Sushma Sharma, Sonika Chauhan
| Weekly Popularity: ⮙7
Research Paper, Zoology, India, Volume 6 Issue 11, November 2017
Pages: 2128 - 2132Effect of an Organophosphate Insecticide, Dimethoate, on Antioxidant Enzymes of the Fish Nile Tilapia, (Oreochromis niloticus) (L.)
Ajitha B.S., C.A. Jayaprakas
| Weekly Popularity: ⮙1
Research Paper, Zoology, India, Volume 6 Issue 12, December 2017
Pages: 656 - 661Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle
Sushma Sharma, Anupam Pundir
| Weekly Popularity: ⮙5
Research Paper, Zoology, India, Volume 5 Issue 9, September 2016
Pages: 765 - 767Analysis of Oxidative Stress Responses in Copper Exposed Catla catla
Gutha Rajasekar, Dr. C Venkatakrishnaiah
Similar Articles with Keyword 'Superoxide dismutase'
Research Paper, Zoology, India, Volume 4 Issue 9, September 2015
Pages: 881 - 884Antioxidant Activity of Root of Achyranthes Aspera and its Comparison with Melatonin in Recovery of Oxidative Stress
Nisreen Husain, Anil Kumar
| Weekly Popularity: ⮙1
Research Paper, Zoology, India, Volume 6 Issue 12, December 2017
Pages: 656 - 661Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle
Sushma Sharma, Anupam Pundir
| Weekly Popularity: ⮙5
Research Paper, Zoology, India, Volume 5 Issue 9, September 2016
Pages: 765 - 767Analysis of Oxidative Stress Responses in Copper Exposed Catla catla
Gutha Rajasekar, Dr. C Venkatakrishnaiah
Similar Articles with Keyword 'Catalase'
| Weekly Popularity: ⮙5
Research Paper, Zoology, India, Volume 6 Issue 5, May 2017
Pages: 1988 - 1992Role of Vitamin C in Attenuation of Carbon Tetrachloride Induced Toxicity in Heart of Mice
Sushma Sharma, Babita Kumari
Research Paper, Zoology, India, Volume 4 Issue 9, September 2015
Pages: 881 - 884Antioxidant Activity of Root of Achyranthes Aspera and its Comparison with Melatonin in Recovery of Oxidative Stress
Nisreen Husain, Anil Kumar
| Weekly Popularity: ⮙7
Research Paper, Zoology, India, Volume 6 Issue 11, November 2017
Pages: 2128 - 2132Effect of an Organophosphate Insecticide, Dimethoate, on Antioxidant Enzymes of the Fish Nile Tilapia, (Oreochromis niloticus) (L.)
Ajitha B.S., C.A. Jayaprakas
| Weekly Popularity: ⮙1
Research Paper, Zoology, India, Volume 6 Issue 12, December 2017
Pages: 656 - 661Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle
Sushma Sharma, Anupam Pundir
| Weekly Popularity: ⮙5
Research Paper, Zoology, India, Volume 5 Issue 9, September 2016
Pages: 765 - 767Analysis of Oxidative Stress Responses in Copper Exposed Catla catla
Gutha Rajasekar, Dr. C Venkatakrishnaiah