International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064

Research Paper | Dental Science | Iraq | Volume 6 Issue 11, November 2017

Micro Pericytes Coverage in Relation to Different Grades of Oral Squamous Cell Carcinoma

Intisar Abdel-Jabbar Al-Sarraf, Ban F. Al-Dorobai

Background Angiogenesis is an important step in Oral Squamous Cell Carcinoma (OSCC) growth, progression, and metastasis. Micro Vessel Density (MVD) can reflect the angiogenic rate but not gives knowledge about the efficiency state of newly formed vessels. Measuring of micro vessel pericytes coverage index (MPI) for these blood vessels can determine the degree of their maturation. Aim of the study this study established to determine the association of between MVD, MPI and clinicopathological parameter of OSCC. Material and Methods Retrospective 36 formalin- fixed, paraffin-embedded tissue blocks histologically diagnosed as OSCC were examined for MVD and MPI were assessed by conventional immunohistochemistry staining using anti-CD105 and anti -SMA antibodies respectively. Results Highly significant association of MPI and histological grade of OSCC (P=0.000), while no significant difference between MVD and clinicopathological parameter of OSCC. Conclusion Both of MVD (using CD105) and MPI can considered as signs of the angiogenic and functional status of a tumor vascularity.

Keywords: Oral Squamous Cell Carcinoma, Pericytes, Micro Vessel Density

Edition: Volume 6 Issue 11, November 2017

Pages: 2213 - 2216


How to Cite this Article?

Intisar Abdel-Jabbar Al-Sarraf, Ban F. Al-Dorobai, "Micro Pericytes Coverage in Relation to Different Grades of Oral Squamous Cell Carcinoma", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20178460, Volume 6 Issue 11, November 2017, 2213 - 2216

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