Formulation & Evaluation of Fast Dissolving Oral Thin Film of Ropinirole HCl
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Pharmaceutical Science | India | Volume 6 Issue 11, November 2017

Formulation & Evaluation of Fast Dissolving Oral Thin Film of Ropinirole HCl

Dipak P. Savant

The present work aimed at preparing fast dissolving oral thin films of Ropinirole Hydrochloride with the purpose ofdeveloping a dosage form for a very quick onset of action, which is very convenient for administration, withoutthe problem of swallowing and using water. The film of Ropinirole Hydrochloride was prepared by usingpolymers such as polyethylene oxide and glycerine as plasticizer, by a solvent casting method. The formulated fast dissolving films were evaluated for physical characteristics such as uniformity of weight, thickness, folding endurance, drug content uniformity, surface pH and percentage elongation, tensile strength using texture analyser. The formulations were subjected to disintegration, In-vitro drug release tests. The FTIR and DSC studies revealed that no physicochemical interaction between excipients and drug. Fast dissolving film ofRopinirole Hydrochloride containing polyethylene oxide as polymer showed (99.18 0.78 %) drug release at 60 sec. Percentagecontent uniformity (99.90 1.25 %). Fastdissolving films of Ropinirole Hydrochloride can be considered suitable for clinical use in the treatment ofparkinsons disease and rest leg syndrome, where a quicker onset of action for a dosage form is desirable alongwith the convenience of administration.

Keywords: Fast dissolving film of Ropinirole Hydrochloride, Polyethylene oxide, SolventCasting method, Parkinson disease, Texture analyser, Atomic force Microscopy, XRD, and SEM scanning electron microscopy

Edition: Volume 6 Issue 11, November 2017

Pages: 1616 - 1625

Share this Article

How to Cite this Article?

Dipak P. Savant, "Formulation & Evaluation of Fast Dissolving Oral Thin Film of Ropinirole HCl", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20178274, Volume 6 Issue 11, November 2017, 1616 - 1625

77 PDF Views | 59 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'XRD'

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 11, November 2017

Pages: 1616 - 1625

Formulation & Evaluation of Fast Dissolving Oral Thin Film of Ropinirole HCl

Dipak P. Savant

Share this Article

Research Paper, Pharmaceutical Science, India, Volume 8 Issue 9, September 2019

Pages: 1274 - 1287

Desloratadine Microemulsion Based Solid Lipid Nanoparticles

Varsha Dute, Vijay Mahajan, Amol Deshmukh

Share this Article

Research Paper, Pharmaceutical Science, Indonesia, Volume 9 Issue 4, April 2020

Pages: 958 - 961

The Effect of Increasing Solubility with Cosolven and PVP on the Preparation and Characterization of Brown Seaweed Extract (Sargassum Polycystum) Nanoparticle as Antioxidants

Kartiningsih, Deni Rahmat, Rika Sari Dewi, Anarisa Budiarti, Gita Serafika Shannon

Share this Article

Research Paper, Pharmaceutical Science, India, Volume 9 Issue 2, February 2020

Pages: 149 - 156

Enhancing the Oral Bioavailability of Poorly Water Soluble BCS Class IV Drug Docetaxel Using Mesoporous Silica Nanoparticles

Pritesh. V. More, Dr. Mrudula. H. Bele, Jignesha. A. Mhatre, Shweta. J. Gangurde, Sunil. B. Rathod, Sachin. S. Warkad

Share this Article
Top