International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




Downloads: 111 | Views: 127

Research Paper | Biochemistry | Egypt | Volume 6 Issue 11, November 2017


Olive Leaves (Olea europaea, L.) Improve Insulin-like Growth Factor (IGF) System Implications Induced by High Fat-High Sucrose Diet

Amira Abd El-Rhman | Eman Hassan


Abstract: Insulin-like growth factors system consists of insulin-like growth factors (IGF-I and II) as ligands, IGF receptors and family of six high-affinity IGF binding proteins (IGFBPs). The aim of this study is to determine the effect of olive leaves administration either in the form of aqueous (AOLE) or ethanolic (EOLE) extracts on implications of IGF system induced by feeding on high fat-high sucrose diet. Animals were randomly separated into four groups. The first group fed on balanced diet as a control group, the second group fed on high fat-high sucrose diet, the third group fed on HF-HS diet + AOLE in oral dose of (500mg/kgbw) and the fourth group fed on HF-HS diet + EOLE in oral dose of (500mg/kgbw). Serum glucose, insulin, lipogenesis factors as well as inflammatory biomarkers and TAC, serum GH, IGF-I, IGFBP-1, IGFBP-3 were estimated. Results indicated that feeding on HF-HS diet significantly increases serum glucose, insulin and results in bad lipid profile with increased inflammatory markers and reduced TAC, in addition to disturbance in serum GH and IGF system parameters level. While, consuming either AOLE or EOLE significantly increased insulin sensitivity, and improved IGF system implications and associated inflammation, furthermore, EOLE had better effect than AOLE.


Keywords: IGF, insulin growth factor, IGFBP, insulin resistance, olive leaves, AOLE, EOLE


Edition: Volume 6 Issue 11, November 2017,


Pages: 1210 - 1218


How to Download this Article?

Type Your Email Address below to Download the Article PDF


How to Cite this Article?

Amira Abd El-Rhman, Eman Hassan, "Olive Leaves (Olea europaea, L.) Improve Insulin-like Growth Factor (IGF) System Implications Induced by High Fat-High Sucrose Diet", International Journal of Science and Research (IJSR), Volume 6 Issue 11, November 2017, pp. 1210-1218, https://www.ijsr.net/get_abstract.php?paper_id=ART20178210



Similar Articles with Keyword 'insulin resistance'

Downloads: 1

Research Paper, Biochemistry, India, Volume 10 Issue 10, October 2021

Pages: 495 - 496

To Study the Levels of Insulin Resistance in Polycystic Ovary Syndrome

Ankita Sharma [7] | Vaishali Mahendra [2] | Deepa Thadani [4] | G.G. Kaushik [4]

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Masters Thesis, Biochemistry, India, Volume 11 Issue 8, August 2022

Pages: 859 - 863

Assessment of Serum Amylase in Type-II Diabetes Mellitus Patients with a Putative Link to Pancreatic Function

Alisha Narula

Share this Article



Top