The Effect of Ligand Exchange and Group Substituent on Biological Activity of Anticancer Ruthenium (III) Complexes (NAMI-A)
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Downloads: 113

Research Paper | Chemistry | Iraq | Volume 6 Issue 11, November 2017

The Effect of Ligand Exchange and Group Substituent on Biological Activity of Anticancer Ruthenium (III) Complexes (NAMI-A)

Ahmed Abdul Sattar Ali

The most spread illnesses nowadays and be afraid so far largely in the world are Cancer Diseases because these illnesses represent complicated and tricky to cure. The main methods of new cancer curing is drug therapy. cell killing (cytotoxic) and cell stabilizing (cytostatic) are two wide categories medications used to fight cancer. Many ruthenium based metallodrugs for anticancer diseases has produced as alternates to platinum compounds, the first ruthenium metallodrug enter clinical trials was NAMI-A trans- [tetrachloro (DMSO) (imidazole) ruthenate (III)], this compound explain to have low toxicity and high selectivity against solid tumor metastases when pharmacologically effectiveness doses. In this paper, we describe the building, characterization and designing crystal structure of a novel ruthenium complex, NAMI-A trans- [tetrachloro (DMSO) (imidazole) ruthenate (III)] and its derivative based on density functional theory (DFT) method using Gaussian 03 program Gaussian 2003. The frontier molecular orbital energies HOMO, LUMO, Mulliken charges distribution, complex activity, and stability of the complexes were discussed. The obtained results of building complexes in addition to standard complex are explained that both (C2, C3, C6, C7) are more suitable as anticancer activity compared toward standard complex (C1), while (C4, C5) is lower activity than (C1)

Keywords: Cancer Diseases, NAMI-A, ruthenium III metallodrug, density functional theory DFT, dimethyl sulfoxide DMSO, HOMO, LUMO energies

Edition: Volume 6 Issue 11, November 2017

Pages: 1800 - 1811

Share this Article

How to Cite this Article?

Ahmed Abdul Sattar Ali, "The Effect of Ligand Exchange and Group Substituent on Biological Activity of Anticancer Ruthenium (III) Complexes (NAMI-A)", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20177535, Volume 6 Issue 11, November 2017, 1800 - 1811

Enter Your Email Address




Similar Articles with Keyword 'HOMO'

Downloads: 13 | Monthly Hits: ⮙13

Comparative Studies, Chemistry, India, Volume 10 Issue 4, April 2021

Pages: 831 - 840

Comparative Studies on Soil Quality Evaluation (For Heavy Metals) in Coastal Region of PSR Nellore Dist, Andhra Pradesh, India

C. Masthan, P. Muni Nagendra Prasad, O. Audi Seshaiah, Y. V. Rami Reddy

Share this Article

Downloads: 88 | Weekly Hits: ⮙1 | Monthly Hits: ⮙10

Research Paper, Chemistry, India, Volume 3 Issue 9, September 2014

Pages: 2399 - 2403

Eco Friendly Egg Shell Mediated Aldol Condensation

T. Clarina, Beyo Melin Valentina, Dr. V. Rama

Share this Article

Downloads: 106

Research Paper, Chemistry, India, Volume 4 Issue 10, October 2015

Pages: 1603 - 1611

Experimental and Theoretical Vibrational Spectroscopic Study of Schiff base Derived from 4-Amino Antipyrine- A Quantum Chemical Study

Kishor Arora, Anu Parmar

Share this Article

Downloads: 111

Research Paper, Chemistry, India, Volume 4 Issue 9, September 2015

Pages: 1352 - 1357

Semi-Empirical Study of Schiff base Compounds Derived from 4-Dimethylaminoantipyrine

Parmar Anu, Arora Kishor

Share this Article

Downloads: 112

Research Paper, Chemistry, India, Volume 6 Issue 2, February 2017

Pages: 2190 - 2195

Yellow Luminescence from LaAlO3:Sm3+ Nano-Phosphors Prepared by Sol-Gel Technique

Subhash Chand, Ishwar Singh

Share this Article

Similar Articles with Keyword 'LUMO energies'

Downloads: 113

Research Paper, Chemistry, Iraq, Volume 6 Issue 11, November 2017

Pages: 1800 - 1811

The Effect of Ligand Exchange and Group Substituent on Biological Activity of Anticancer Ruthenium (III) Complexes (NAMI-A)

Ahmed Abdul Sattar Ali

Share this Article

Downloads: 118

Research Paper, Chemistry, India, Volume 4 Issue 6, June 2015

Pages: 615 - 620

Global and Reactivity Descriptors Studies of Cyanuric Acid Tautomers in Different Solvents by using of Density Functional Theory (DFT)

Numbury Surendra Babu, Didugu Jayaprakash

Share this Article



Top