New CFIA / Merging Zones Technique for Determination of Captopril in Pure and Pharmaceutics Dosage forms through the Oxidation / Reduction Reaction of Drug with Cu(II)- Neocuproine Complex via Spectrophotometric Detection
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



Downloads: 139 | Weekly Hits: ⮙3 | Monthly Hits: ⮙12

Research Paper | Chemistry | Iraq | Volume 6 Issue 10, October 2017

New CFIA / Merging Zones Technique for Determination of Captopril in Pure and Pharmaceutics Dosage forms through the Oxidation / Reduction Reaction of Drug with Cu(II)- Neocuproine Complex via Spectrophotometric Detection

Bushra B. Qassim, Ahmed A. Alwan

A new simplicity, accuracy, rapid and sensitive batch and merging zones-flow injection analysis spectrophotometric ways for estimation of captopril in fine material forms and pharmaceutical formulations were suggested. The procedure was depended on the oxidation and reduction reaction of CPL with Cu (II) Neocuproine complex as reagent in presence of acetate buffer solution (pH=5) as a medium to form colored complex Cu (I) -neocuproine chelate that was measured at 454 nm. The optimized FIA order was able to estimate of CPL. with a throughput 48 sample.h-1, flow rate 1.4 mL/min was used distilled water as a carrier, 51.02 L analyte volume (50 g.ml-1 CPL) with acetate buffer (0.1 M sodium acetate and 0.1 M acetic acid), 49.06 L Neocuproine (2x10-3M), 43.175 L Cu (II) nitrate.3H2O (8x10-3M) for L1, L2 and L3, respectively. Open valve model for sample inject and chemicals that used in the work. Calibration curves of absorbance against concentration sign of Beer, s law is submitted to within the concentrations scope of 1-80 & 3-120.mL-1 of captopril with detection limits 1.5x10-1, 3.1x10-2 g.ml-1 and quantification limits, 5x10-1, 1.03x10-2 g/mL of captopril for batch and CFIA systems, respectively. a correlation coefficient (r) were 0.9960, 0.9981 and percentage linearity (r2 %) were 99.60 %, 99.81 %, repeatability (RSD %) (n=7) were 0.112 and 0.26 for estimation of captopril with concentration 30 & 70 g.mL-1. The suggested procedure carried out successfully for estimation of CPL. in pharmaceutical formulations and statistical analysis of the values comparing with results by United States Pharmacopoeia ( USP) were also reported.

Keywords: Captopril, Neocuproine, Cuppric ion, FIA - merging zones, Spectrophotometric determination

Edition: Volume 6 Issue 10, October 2017

Pages: 974 - 986

Share this Article

How to Cite this Article?

Bushra B. Qassim, Ahmed A. Alwan, "New CFIA / Merging Zones Technique for Determination of Captopril in Pure and Pharmaceutics Dosage forms through the Oxidation / Reduction Reaction of Drug with Cu(II)- Neocuproine Complex via Spectrophotometric Detection", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20177121, Volume 6 Issue 10, October 2017, 974 - 986

Enter Your Registered Email Address





Similar Articles with Keyword 'Spectrophotometric determination'

Downloads: 151 | Monthly Hits: ⮙11

Research Paper, Chemistry, Iraq, Volume 7 Issue 8, August 2018

Pages: 39 - 43

p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction

Nabeel S. Othman Ali M. Asaad

Share this Article

Downloads: 105 | Weekly Hits: ⮙1

Research Paper, Chemistry, India, Volume 3 Issue 7, July 2014

Pages: 1546 - 1550

Sensitive Spectrophotometric Determination of Chlorpyrifos in Different Environmental and Biological Samples

Vindhiya Patel, Manish Kumar Rai, Prashant Mundeja, Joyce Rai

Share this Article

Downloads: 108 | Weekly Hits: ⮙2 | Monthly Hits: ⮙8

Research Paper, Chemistry, Iraq, Volume 6 Issue 12, December 2017

Pages: 1131 - 1138

Normal Flow and Stopped Flow Injection Spectrophotometric Determination of Quercetin Dihydrate Dietary Supplements

Sadeem Subhi Abed, Hinda Ali Mahmood

Share this Article

Downloads: 110 | Weekly Hits: ⮙5 | Monthly Hits: ⮙16

Research Paper, Chemistry, Egypt, Volume 4 Issue 12, December 2015

Pages: 1611 - 1615

A Developed Spectrophotometric Method for Thorium Determination using Alizarin Red S Dye in Different Types of its Bearing Rocks

Hisham K. Fouad, Saeyda A. Abu Elenein, Randa M. Elrakaiby, Shaimaa S. Abdulmoteleb

Share this Article

Downloads: 114 | Weekly Hits: ⮙1

Research Paper, Chemistry, India, Volume 8 Issue 1, January 2019

Pages: 1352 - 1354

Spectrophotometric Determination of Palladium (II) & Platinum (IV)

Gollapudi Venkata Ramana Murthy, Mallavarapu Umamahesh, Seetha Jaswanth, Akepogu Prasad, Amara Venkateswara Rao

Share this Article



Top