Antibiotic Resistance Pattern of Isolates in Intensive Care Unit and Source of Nosocomial Infection in a Tertiary Care Hospital, Dhaka, Bangladesh
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064


Amazon Sale


Research Paper | Medical Microbiology | Bangladesh | Volume 6 Issue 9, September 2017

Antibiotic Resistance Pattern of Isolates in Intensive Care Unit and Source of Nosocomial Infection in a Tertiary Care Hospital, Dhaka, Bangladesh

Mirza Nazim Uddin, NurunNahar Mawla, Zahidul Hasan, Faridul Islam, Anowar Hossain

Background Infections with resistance bacteria threatens the effectiveness of antibiotic treatment with increased morbidity, mortality and hospital costs. Rapid emergence of multi-drug resistance necessitates monitoring microbial isolates with their resistance pattern. During 2015-16, this study conducted in Square hospital ICU to see pattern of pathogens, their antimicrobial resistance and presence of MRSA, ESBL and CRE in nosocomial infections. Methods Specimens from ICU patients processed for isolation, identification, tested antimicrobial resistance and production of ESBL, CRE and MRSA following standard methods. Admitted patients were monitored and data analyzed for pattern of hospital-acquired infections. Results Of 2, 447 pathogens, majority yielded from tracheal aspirates (37 %) compared to others. Among pathogens, Klebsiella were 21.6 %, E. coli 12 %, Pseudomonas 9.9 % and Acinatobacterspp 9.8 %, while Staphylococci were 8.3 %, Enterococci 3.4 %, Pneumococci 2 % and Candida were 13 %. Overall 78 % E. coli were resistant to multiple drugs, of which 82 % resistant to cefuroxime, 75 % to amoxiclav and ciprofloxacin each, 69 % to cefixime, 67 % to ceftriaxone and 66 % to cefepime. Majority Klebsiella were resistant to common antibiotics, except meropenem (50 %). About 40 % Pseudomonas and Acinatobacter were resistant to common antibiotics except colistin and polymyxin B. About 58 % of E. coli and 24 % Klebsiella produced ESBL, with 48 % resistant to carbapenem. Penicillin and amoxicillin resistance were 90 % among gram positive bacteria and MRSA Producing Staphylococci was 47 % with no resistance to vancomycin. Among 277 hospital-acquired infections, Ventilator associated pneumonia (VAP) was 56 % followed by 23.1 % UTI and 10.5 % BSI. Conclusion Emergence of MDR bacteria among ICU patients is a global problem as they contract hospital-acquired infections more commonly from foci within hospitals. Higher prevalence of MDR infection in ICU of SHL is not an exception. Challenges remain in treating patients with CRE, ESBL and MRSA infections. Strengthening antimicrobial stewardship, monitoring effectiveness of antibiotic usage and infection control program could reduce this critical problem.

Keywords: Antimicrobial resistance, Hospital acquired infection, Intensive care unit

Edition: Volume 6 Issue 9, September 2017

Pages: 1117 - 1124

Share this Article

How to Cite this Article?

Mirza Nazim Uddin, NurunNahar Mawla, Zahidul Hasan, Faridul Islam, Anowar Hossain, "Antibiotic Resistance Pattern of Isolates in Intensive Care Unit and Source of Nosocomial Infection in a Tertiary Care Hospital, Dhaka, Bangladesh", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20176855, Volume 6 Issue 9, September 2017, 1117 - 1124

67 PDF Views | 60 PDF Downloads

Download Article PDF


Amazon Sale


Similar Articles with Keyword 'Antimicrobial resistance'

Research Paper, Medical Microbiology, India, Volume 9 Issue 5, May 2020

Pages: 1592 - 1595

Bacterial Profile and Antibiotic Susceptibility Pattern of Lower Respiratory Tract Infections in a Tertiary Care Hospital

Manoj Kumar, Nayannika Lakra, Ashok Kumar Sharma, Amber Prasad, Kumari Seema

Share this Article

Research Paper, Medical Microbiology, Bangladesh, Volume 6 Issue 9, September 2017

Pages: 1117 - 1124

Antibiotic Resistance Pattern of Isolates in Intensive Care Unit and Source of Nosocomial Infection in a Tertiary Care Hospital, Dhaka, Bangladesh

Mirza Nazim Uddin, NurunNahar Mawla, Zahidul Hasan, Faridul Islam, Anowar Hossain

Share this Article

Research Paper, Medical Microbiology, Libya, Volume 7 Issue 11, November 2018

Pages: 381 - 391

The Study of the Relationship between the Dominant Bacterial Species and Antimicrobial Susceptibility Tests Derna-East Libya

Mabroka H. Tarfaya, Mona A. El-mahdi, Zahra M. Bomousa

Share this Article

Similar Articles with Keyword 'Intensive care unit'

Research Paper, Medical Microbiology, Bangladesh, Volume 6 Issue 9, September 2017

Pages: 1117 - 1124

Antibiotic Resistance Pattern of Isolates in Intensive Care Unit and Source of Nosocomial Infection in a Tertiary Care Hospital, Dhaka, Bangladesh

Mirza Nazim Uddin, NurunNahar Mawla, Zahidul Hasan, Faridul Islam, Anowar Hossain

Share this Article

Research Paper, Medical Microbiology, Bangladesh, Volume 7 Issue 1, January 2018

Pages: 607 - 613

Microbial Agents in Ventilation Associated Pneumonia (VAP) and their Resistance Pattern in Patients of ICU of Square Hospital, Bangladesh: An Observation for Two and a Half Year

Mirza Nazim Uddin, Raihan Rabbani, Nurun Nahar Mawla, Ahmed Mursel Anam, Arifa Hossain, Tahsin Monaem, Anowar Hossain

Share this Article

Research Paper, Medical Microbiology, India, Volume 8 Issue 8, August 2019

Pages: 1281 - 1284

A Study to Assess the Bacterial Pathogens of Ventilator Associated Pneumonia in the Intensive Care Unit Patients in a Tertiary Care Hospital in South India

Silpha V. S., Aruna

Share this Article
Top