Dissertation Chapters | Pediatric Specialty | India | Volume 6 Issue 8, August 2017
A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. In this study we compare the diagnostic yield of geneXpert and smear microscopy in detection of Tuberculosis in children. We have compared sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of GeneXpert with smear microscopy in detection of Mycobacterium Tuberculosis in children. Out of the total 100 cases of suspected tuberculosis evaluated in a tertiary care hospital, 80 patients were clinically TB positive and 20 patients were clinically TB negative. Both genexpert and AFB smear microscopy showed 100 % specificity and positive predictive value. However sensitivity of genexpert was 48.7 % & that of AFB smear was 16.3. Negative predictive value of genexpert was 32.8 % & that of AFB smear microscopy was 22.9 %. Sensitivity of GeneXpert was approximately 3 times higher than AFB smear microscopy and Negative predictive value of GeneXpert is also higher as compared to AFB smear microscopy. Hence genexpert was found to be a better diagnostic test as compared to smear microscopy and can significantly reduce false negatives and the delay in treatment initiation, reducing premature death and ongoing transmission
Keywords: GeneXpert, microscopy, sensitivity, specificity, positive predictive value, negative predictive value
Edition: Volume 6 Issue 8, August 2017
Pages: 1616 - 1619
How to Cite this Article?
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary, "A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20176297, Volume 6 Issue 8, August 2017, 1616 - 1619
1 PDF Views | 7 PDF Downloads
Video Lecture of Above Article is Not Available Yet
You be the First to Request! Press the Button below!
Similar Articles with Keyword 'microscopy'
Dissertation Chapters, Pediatric Specialty, India, Volume 6 Issue 8, August 2017
Pages: 1616 - 1619A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Research Paper, Pediatric Specialty, India, Volume 4 Issue 10, October 2015
Pages: 1565 - 1576Reliability of Urine Dipstick Analysis and Microscopy as a Predictor of Urinary Tract Infection
Manoj Sankar
Research Paper, Pediatric Specialty, India, Volume 6 Issue 1, January 2017
Pages: 290 - 295Yale Observation Score for Prediction of Critical Illness in 3-36 Months Old Febrile Children
Dr Karuna Thapar, Dr Preeti Malhotra, Dr Ishpreet Singh
Case Studies, Pediatric Specialty, India, Volume 4 Issue 5, May 2015
Pages: 742 - 744Case Report: Griscelli Syndrome ? A Unique Pigmentary Defect
Dr. Ashish Lothe, Dr. Leena Dhande
Similar Articles with Keyword 'sensitivity'
Informative Article, Pediatric Specialty, India, Volume 8 Issue 9, September 2019
Pages: 1510 - 1511Herpes Associated Erythema Multiforme: A Diagnostic Dilemma
Palani Rajan, Rajkumar, Arulraj Russelian
Research Paper, Pediatric Specialty, India, Volume 6 Issue 3, March 2017
Pages: 1327 - 1329Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia
Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar
Dissertation Chapters, Pediatric Specialty, India, Volume 6 Issue 8, August 2017
Pages: 1616 - 1619A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Research Paper, Pediatric Specialty, India, Volume 4 Issue 10, October 2015
Pages: 1565 - 1576Reliability of Urine Dipstick Analysis and Microscopy as a Predictor of Urinary Tract Infection
Manoj Sankar
Research Paper, Pediatric Specialty, India, Volume 7 Issue 3, March 2018
Pages: 183 - 190A Comparative Study using the Short Sensory Profile by the Caregivers on the Performance of Children With and Without Autism Spectrum Disorders
Hetal Jagdishkumar Tripathi, Titiksh Vijeshkumar Varma, Krupa Babulal Prabhakar
Similar Articles with Keyword 'specificity'
Research Paper, Pediatric Specialty, India, Volume 6 Issue 3, March 2017
Pages: 1327 - 1329Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia
Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar
Dissertation Chapters, Pediatric Specialty, India, Volume 6 Issue 8, August 2017
Pages: 1616 - 1619A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Research Paper, Pediatric Specialty, India, Volume 4 Issue 10, October 2015
Pages: 1565 - 1576Reliability of Urine Dipstick Analysis and Microscopy as a Predictor of Urinary Tract Infection
Manoj Sankar
Research Paper, Pediatric Specialty, India, Volume 6 Issue 1, January 2017
Pages: 290 - 295Yale Observation Score for Prediction of Critical Illness in 3-36 Months Old Febrile Children
Dr Karuna Thapar, Dr Preeti Malhotra, Dr Ishpreet Singh
Research Paper, Pediatric Specialty, India, Volume 5 Issue 4, April 2016
Pages: 1058 - 1062Screening of Congenital Heart Disease in Newborns by Physical Examination and Pulse Oximetry in a Tertiary Care Center in Western Maharashtra
Dr. Snehal Satish Surana, Dr. Chandrashekhar Aundhakar
Similar Articles with Keyword 'positive predictive value'
Research Paper, Pediatric Specialty, India, Volume 6 Issue 3, March 2017
Pages: 1327 - 1329Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia
Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar
Dissertation Chapters, Pediatric Specialty, India, Volume 6 Issue 8, August 2017
Pages: 1616 - 1619A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Research Paper, Pediatric Specialty, India, Volume 4 Issue 10, October 2015
Pages: 1565 - 1576Reliability of Urine Dipstick Analysis and Microscopy as a Predictor of Urinary Tract Infection
Manoj Sankar
Research Paper, Pediatric Specialty, India, Volume 6 Issue 1, January 2017
Pages: 290 - 295Yale Observation Score for Prediction of Critical Illness in 3-36 Months Old Febrile Children
Dr Karuna Thapar, Dr Preeti Malhotra, Dr Ishpreet Singh
Research Paper, Pediatric Specialty, India, Volume 5 Issue 4, April 2016
Pages: 1058 - 1062Screening of Congenital Heart Disease in Newborns by Physical Examination and Pulse Oximetry in a Tertiary Care Center in Western Maharashtra
Dr. Snehal Satish Surana, Dr. Chandrashekhar Aundhakar
Similar Articles with Keyword 'negative predictive value'
Research Paper, Pediatric Specialty, India, Volume 6 Issue 3, March 2017
Pages: 1327 - 1329Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia
Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar
Dissertation Chapters, Pediatric Specialty, India, Volume 6 Issue 8, August 2017
Pages: 1616 - 1619A Comparative Study between Genexpert and Smear Microscopy for Diagnosis of Tuberculosis in Paediatric Patients
Dr Nita Sutay, Dr Swati Jha, Dr Devanand Chaudhary
Research Paper, Pediatric Specialty, India, Volume 4 Issue 10, October 2015
Pages: 1565 - 1576Reliability of Urine Dipstick Analysis and Microscopy as a Predictor of Urinary Tract Infection
Manoj Sankar
Research Paper, Pediatric Specialty, India, Volume 6 Issue 1, January 2017
Pages: 290 - 295Yale Observation Score for Prediction of Critical Illness in 3-36 Months Old Febrile Children
Dr Karuna Thapar, Dr Preeti Malhotra, Dr Ishpreet Singh
Research Paper, Pediatric Specialty, India, Volume 5 Issue 4, April 2016
Pages: 1058 - 1062Screening of Congenital Heart Disease in Newborns by Physical Examination and Pulse Oximetry in a Tertiary Care Center in Western Maharashtra
Dr. Snehal Satish Surana, Dr. Chandrashekhar Aundhakar