International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


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Research Paper | Chemistry | Iraq | Volume 6 Issue 8, August 2017


Design ? Syntheses, Characterization and Evaluation Antimicrobial Activity for Some azobenzen-p, p-disubstituted with (3, O), (3, N-) substitute, (3, H) -quinazolin-4-one-2yl and 4-substituted quinazolin-2yl moieties

Zakaria H. Aiube, Zainab A. Jabarah


Abstract: Two of 3, O-substituted quinazoline-4-one namely azobenzen-p, p'-di [3, O-benzyl-4 (3H)quinazolin-4-one-2yl], and azobenzen-p, p'-di [3, O-acetyl-4 (3H)quinazolin-4-one-2yl], were synthesized from azobenzen-p, p'-di [3-hydroxy-4 (3H)quinazolin-4-one-2yl]. Two of 3-N-substituted quinazoline-4-one namely azobenzen-p, p'-di [3, N-benzensulphonylamide-4 (3H)quinazolin-4-one-2yl], and azobenzen-p, p'-di [3, N- (4'-nitrofurfurylidine-2'-yl imino)-4 (3H)quinazolin-4-one-2yl], were synthesis from azobenzen-p, p'-di [3-amino-4 (3H)quinazolin-4-one-2yl]. azobenzen-p, p'-di [3-hydro-4 (3H)quinazolin-4-one-2yl], was synthesized from azobenzen-p, p'-di (3, 1-benzoaxzine-4-one-2yl], which was used for synthesis azobenzen-p, p'-di [4-chloro-quinazolin-2yl], while its treatment with p-toluidine and ethylene diamine give azobenzen-p, p'-di [4-N-toludino-quinazolin-2yl], and azobenzen-p, p'-di [4-N-aminoethylamine-quinazolin-2yl] respectively. All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR and mass spectral analyses. All synthesized compounds, were examined as antibacterial agents against gm (+ve and ?ve) bacteria, and antifungal agents. Results showed abroad extended excellent to moderate effects as antibacterial and antifungal agents.


Keywords: di-substituted-quinazolinone, antibacterial, antifungal


Edition: Volume 6 Issue 8, August 2017,


Pages: 1461 - 1467


How to Cite this Article?

Zakaria H. Aiube, Zainab A. Jabarah, "Design ? Syntheses, Characterization and Evaluation Antimicrobial Activity for Some azobenzen-p, p-disubstituted with (3, O), (3, N-) substitute, (3, H) -quinazolin-4-one-2yl and 4-substituted quinazolin-2yl moieties", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20176229, Volume 6 Issue 8, August 2017, 1461 - 1467

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