International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 125

Research Paper | Pharmaceutical Science | India | Volume 6 Issue 6, June 2017


Characterization and Anti-Tubercular Evaluation of Mannich base Substituted Imidazole Derivatives

Karthika.S, Girija.K


Abstract: The present research has focused to characterize and evaluate anti-tubercular activity of Mannich base substituted imidazole derivatives. A new series of substituted imidazole derivatives were synthesized by condensation of O-Phenylenediamine with glacial acetic acid and also with different amino acids (valine, glycine) which on further treated with secondary amines in the presence of formaldehyde. All these compounds were evaluated for in-silico anti-tubercular activity (docking on Cytochrome P450 14 -sterol demethylase) and also screened in-vitro anti-tubercular activity at various concentrations against the Mycobacterium tuberculosis H37RV strain by Proportional Sensitivity test method. All compounds were characterized by FT-IR, 13CNMR, 1HNMR and elemental analysis (CHNO). The titled compound exhibited good binding property with molecular target. The compounds (1a & 2a) showed Sensitivity against H37RV strain.


Keywords: Imidazole, Docking, H37RV, Proportional Sensitivity test


Edition: Volume 6 Issue 6, June 2017,


Pages: 984 - 990


How to Cite this Article?

Karthika.S, Girija.K, "Characterization and Anti-Tubercular Evaluation of Mannich base Substituted Imidazole Derivatives", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20174469, Volume 6 Issue 6, June 2017, 984 - 990

How to Share this Article?

Enter Your Email Address


Top