International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 130 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Pharmaceutical Science | India | Volume 6 Issue 5, May 2017


Formulation and Evaluation of Sustained Release Bilayer Tablets of Verapamil Hydrochloride and Enalapril Maleate

Vivek.V | Deattu.N | Elango.K | Dhanalakshmi.K


Abstract: The present study is aimed to develop a sustained release bilayer tablet of a combination of Verapamil hydrochloride and Enalapril maleate which possess synergistic effect in mild to moderate hypertension in the doses 240 mg and 10 mg respectively. The tablets of both the drugs were formulated by direct compression method individually using different ratios of the controlled release hydrophilic polymers such as HPMC K100 and Carbopol 934. All the tablets were subjected to post-compression evaluation parameters such as hardness, friability, weight variation, thickness and drug content and were found to be within the limits. In vitro studies of the formulated tablets were performed in acid buffer pH 1.2 for first 2 hrs and phosphate buffer pH 6.8 for the remaining hours. The optimised formulations of both the drugs (VH 1 & EM 6) which showed release upto 24 hrs were selected for compression into bilayer tablets and post compression studies were evaluated which were found to be comply with the standards. The in vitro drug release data was fitted into various kinetic models which showed that the drug release follows zero order release and the best fit release kinetics was achieved with the Korsmeyer - Peppas model.


Keywords: Verapamil hydrochloride, Enalapril maleate, HPMC K100, Carbopol 934


Edition: Volume 6 Issue 5, May 2017,


Pages: 1174 - 1180


How to Cite this Article?

Vivek.V, Deattu.N, Elango.K, Dhanalakshmi.K, "Formulation and Evaluation of Sustained Release Bilayer Tablets of Verapamil Hydrochloride and Enalapril Maleate", International Journal of Science and Research (IJSR), Volume 6 Issue 5, May 2017, pp. 1174-1180, https://www.ijsr.net/get_abstract.php?paper_id=ART20173475

How to Share this Article?






Similar Articles with Keyword 'Carbopol 934'

Downloads: 86

Research Paper, Pharmaceutical Science, Indonesia, Volume 9 Issue 10, October 2020

Pages: 447 - 451

Dissolution Profile Mucoadhesive Microgranules of Ranitidine HCL using Polymer Combination of Aloe Vera Powder (Aloe vera L.) and Carbopol 934P On AIF and SIF Media with a Line of Identification Approach

Endang Diyah Ikasari | Intan Martha Cahyani

Share this Article

Downloads: 115

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 5, May 2017

Pages: 1064 - 1066

Formulation and Evaluation of Herbal Gel Containing Methanolic Extract of Annonasquamosa Leaves

Mayur Mokashi | Manjusha Dole [2]

Share this Article


Top