International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 124

Research Paper | Chemical Sciences | Iraq | Volume 6 Issue 5, May 2017


Preparation Some New Heterocyclic Compounds Derived from Schiff Bases and Evaluation its Biological Activity

Khitam T. A. Al-Sultani


Abstract: Theresearch include preparation some new 2, 3-dihydroquinazolin-4 (1H) -one and oxazepine derivatives. Schiff bases derivatives (1-5) formation from condensation 4-amino-N- (p-tolylcarbamothioyl) benzamide with some aromatic aldehyde (p-Bromobenzaldehyde, p-Nitrobenzaldehyde, p-Chloro benzaldehyde, 2, 4-di hydroxybenzaldehyde and 2, 4-di methoxybenzaldehyde). The solvent is ethanol and in the presence of glacial acetic acid. Thentwochemicalreagents (anthranilic acid and maleic anhydride) used to cyclization of the prepared Schiff bases to form 2, 3-dihydroquinazolin-4 (1H) -one (6-10), oxazepine (11-15) derivatives respectively. The chemical structure of new synthesized compounds characterized (infrared and some derivatives by Nuclear Magnetic Resonance (1HNMR, 13C-NMR) and measurements some of its physical features and some specific reactions. and checked through T. L. C. Also, The biological activity of some compounds was tested against bacteria.


Keywords: Bases, 2, 3-Dihydroquinazolin-4 1H -one, Oxazepine, Antibacterial


Edition: Volume 6 Issue 5, May 2017,


Pages: 1567 - 1572


How to Cite this Article?

Khitam T. A. Al-Sultani, "Preparation Some New Heterocyclic Compounds Derived from Schiff Bases and Evaluation its Biological Activity", International Journal of Science and Research (IJSR), Volume 6 Issue 5, May 2017, pp. 1567-1572, https://www.ijsr.net/get_abstract.php?paper_id=ART20173442

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