Research Paper | Chemical Sciences | Iraq | Volume 6 Issue 5, May 2017
Preparation Some New Heterocyclic Compounds Derived from Schiff Bases and Evaluation its Biological Activity
Khitam T. A. Al-Sultani
Abstract: Theresearch include preparation some new 2, 3-dihydroquinazolin-4 (1H) -one and oxazepine derivatives. Schiff bases derivatives (1-5) formation from condensation 4-amino-N- (p-tolylcarbamothioyl) benzamide with some aromatic aldehyde (p-Bromobenzaldehyde, p-Nitrobenzaldehyde, p-Chloro benzaldehyde, 2, 4-di hydroxybenzaldehyde and 2, 4-di methoxybenzaldehyde). The solvent is ethanol and in the presence of glacial acetic acid. Thentwochemicalreagents (anthranilic acid and maleic anhydride) used to cyclization of the prepared Schiff bases to form 2, 3-dihydroquinazolin-4 (1H) -one (6-10), oxazepine (11-15) derivatives respectively. The chemical structure of new synthesized compounds characterized (infrared and some derivatives by Nuclear Magnetic Resonance (1HNMR, 13C-NMR) and measurements some of its physical features and some specific reactions. and checked through T. L. C. Also, The biological activity of some compounds was tested against bacteria.
Keywords: Bases, 2, 3-Dihydroquinazolin-4 1H -one, Oxazepine, Antibacterial
Edition: Volume 6 Issue 5, May 2017,
Pages: 1567 - 1572
How to Cite this Article?
Khitam T. A. Al-Sultani, "Preparation Some New Heterocyclic Compounds Derived from Schiff Bases and Evaluation its Biological Activity", International Journal of Science and Research (IJSR), Volume 6 Issue 5, May 2017, pp. 1567-1572, https://www.ijsr.net/get_abstract.php?paper_id=ART20173442
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