Amino Acid Substitution in Hepatitis C Virus Core and Genetic Variation in Interleukin 28? Gene and their Correlation to Interferon Treatment Failure in Chronic HCV Egyptian Patients
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064


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Research Paper | Medicine Science | Egypt | Volume 6 Issue 5, May 2017

Amino Acid Substitution in Hepatitis C Virus Core and Genetic Variation in Interleukin 28? Gene and their Correlation to Interferon Treatment Failure in Chronic HCV Egyptian Patients

Nashwa El-Khazragy, Maiada A. Hussien, Mohamed A. El-Mordy, Amany M. Maher

Hepatitis C virus becomes a one of the top curable chronic diseases worldwide, this was referred to the remarkable efficacy of antiviral therapy, however, many cases showed resistance to interferon/Ribavirin combination therapy. Genetic polymorphism is the major cause of relapse after therapy. To determine whether Hepatitis C virus (HCV) core substitution and IL-28 (rs8099917) play a role in the response to INF/RBV antiviral therapy, 115 HCV chronically infected patients initiated treatment with Peglated INF plus ribavirin (INF/RBV) for 48 weeks were tested for baseline substitution at codon 70 of the viral core protein and for genetic polymorphism in IL-28 rs8099917 (TaqMan Probe assay, Applied Biosystems). In this study, we observed that, TT genotype in IL-28 polymorphism was the favourable genotype as 75 % of this genotype achieved therapeutic success, defined as sustained viral response at 12 weeks of therapy. 23.5 % of studied patients presented a mutant HCV core substitution at core position 70, those were resistant to therapy and failed to achieve a viral response. A multivariate analysis revealed three independent predictors of therapeutic success age40years (P<0.001), IL-28 rs8099917 genotype (P=0.04) and absence of HCV core substitution at position 70 (P<0.001). This study concluded that IL-28 rs8099917 and HCV core mutations can be considered as predictors for therapeutic response to INF/RBV therapy, so those who are affordable should treated with direct acting antiviral drugs (DAAs) rather than INF based therapy to prevent evolution towards end-stage liver disease.

Keywords: Hepatitis C virus, IL-28 rs8099917, INF/RBV antiviral therapy, HCV core substitution

Edition: Volume 6 Issue 5, May 2017

Pages: 1187 - 1192

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Nashwa El-Khazragy, Maiada A. Hussien, Mohamed A. El-Mordy, Amany M. Maher, "Amino Acid Substitution in Hepatitis C Virus Core and Genetic Variation in Interleukin 28? Gene and their Correlation to Interferon Treatment Failure in Chronic HCV Egyptian Patients", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20173368, Volume 6 Issue 5, May 2017, 1187 - 1192

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