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Research Paper | Clinical Chemistry | Iraq | Volume 6 Issue 5, May 2017
Salivary Alpha Amylase as a Marker to Predict Diabetes Mellitus in Children with Family History of Diabetes
Ameena Ryhan Diaji  | Lamia Ibrahim Sood | Rasha Abbas Azeez
Abstract: The overall look of signs of adult serious diseases in children indicates that genetics are important, because the environment had only a short period of time to act. Genealogy of diabetic has been recognized as a significant threat factor of the disease. Family health background symbolizes valuable genomic information because its characterizes the combined connections between ecological, behavioural, and genetics. The aim of this research was to investigate the level of ?-amylase in un-stimulated whole saliva of healthy children in relation to some oral health factors and to family history of diabetes, with the objective to compare salivary amylase stage in children with positive family history of diabetes and those with negative history. Questionnaires were filled by children families consisted of demography, health background and close relatives record of diabetes mellitus, with close relatives record categories were defined by 1st and second relative's. From 100 healthy primary school, saliva examples were gathered for 5- minutes between 900-1100 AM. Flow-rate, Oral plaque and Gingival index were assessed using WHO criteria. Salivary amylase was analysed using EnzyChrom? ?-Amylase Analysis Kit (Quantitative Colorimetric Amylase Determination at 585nm). Considering family history, positive family history of diabetes mellitus was positively, associated with salivary amylase concentration. Children with positive family history of diabetes mellitus showed higher salivary amylase level compared to those with negative family history. According to the knowledge of the effect of diabetes mellitus on saliva, the basement membrane permeability of parotid gland is higher in diabetes mellitus and the components for example amylase, protein and glucose in blood raised, so raising their levels in saliva. This might be due to hormonal and metabolic changes related with disease. In this study Higher levels of alpha-amylase in saliva of children with a family history of diabetes mellitus might be important to recognize children at an increased risk for DM. Considering sex, males created greater salivary circulation amount in comparison to females, however the difference was non-significant. Several straight line regression research revealed that, being amales is expected to reduce salivary amylase by a mean of 11U/L in comparison to women, however non-significance, A good straight line connection was found between age of children and salivary amylase level (r=0.400, P<0.001). Children with higher scores of gingivitis showed higher salivary amylase level (291.1 U/L) compared to those with lower score of gingival index (281.9 U/L).
Keywords: children, unstimulated salivary flow rate, family history of diabetes
Edition: Volume 6 Issue 5, May 2017,
Pages: 589 - 595
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