Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



Downloads: 128 | Weekly Hits: ⮙6 | Monthly Hits: ⮙16

Research Paper | Pediatrics | India | Volume 6 Issue 3, March 2017

Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia

Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar

Introduction During the neonatal period, metabolism of bilirubin is in transition from the fetal stage to the adult stage1. Uridine diphosphoglucuronyl transferase (UDPGT), an important liver enzyme for conjugation and excretion of bilirubin, is detectable at 18 20 weeks of gestation. UDPGT levels in full term neonates are usually less than 0.1 % of adult values. Adult value of this enzyme activity is demonstrable only by 614 weeks of postnatal life2. Synthesis of albumin appears at approximately the 7th-8th wk. in the human fetus and increases in inverse proportion to that of -fetoprotein. Albumin concentrations are low in a neonate (2.5 g/dL), reaching adult levels (3.5 g/dL) after several months.3 Albumin has been described as the bodys tramp steamer, shuttling cargo of various kinds between ports of call. Its load includes bilirubin, free fatty acids, calcium, etc.4 Bilirubin binds to albumin in an equimolar ratio. Free bilirubin is anticipated when the bilirubin- to- albumin (B A) ratio is > 0.8. Around 8.5mg of bilirubin will bind tightly to 1 g of albumin.3 Neonatal Hyperbilirubinemia (NH) is commonest abnormal physical finding during the first week of life. Serum bilirubin over 15 mg % is found in 3 % of normal term neonates.3 Neonatal Hyperbilirubinemia (NH) is the most common cause for readmission during the early neonatal period (6.5 %).5 American Academy of Pediatrics (AAP) recommends that neonate discharged within 48 hours should have a follow-up visit after 48 to 72 hours for any significant jaundice and other problems.6 This recommendation is not appropriate for our country due to poor access to health care facility. NH which may be over looked or delay in recognition by parents, because lack of knowledge. Concern of pediatrician regarding the early discharge is bilirubin encephalopathy sequel occurring in healthy term infants even without hemolysis. 7, 8 Physical examination is not a reliable measure of the serum bilirubin. By predicting the neonates at risk for significant NH early at birth, we can design and implement the follow-up programme in these risk groups, cost effectively. There are studies to predict NH by measuring cord albumin and cord bilirubin individually. The present study is carried out comparing these two variables. Hence the objectives of the study are Comparing Cord Serum Albumin level (CSA) with Cord Serum Bilirubin (CSB) in predicting neonatal hyperbilirubinemia. To know the sensitivity, specificity, Positive predictive value and negative predictive value of CSA and CSB in predicting neonatal jaundice in term neonates. OBJECTIVE 1. Comparing Cord Serum Albumin level (CSA) with Cord Serum Bilirubin (CSB) in predicting neonatal hyperbilirubinemia. 2. To know the sensitivity, specificity, Positive predictive value and negative predictive value of CSA and CSB in predicting neonatal jaundice in term neonates. METHOD Prospective study was performed on 750 healthy term neonates. Relevant maternal history is collected. Cord blood was collected from the healthy term neonates at birth, CSA and CSB measured. Neonate was assessed clinically every day. Total Serum Bilirubin (TSB) and blood group were assessed in neonate during 72-96 hours of life. TSB value 15mg/dl is considered Neonatal Hyperbilirubinemia (NH) which requires intervention like phototherapy (PT) or Exchange transfusion (ExT). RESULT Study cohort is grouped in Group 1 and group 2 based on Cord Serum Albumin level 2.5g/dl and 2.5g/dl, respectively. Based on CSB, study cohort divided into neonates with CSB 4.5mg/dl and CSB 4.5mg/dl. Statistical analysis done for correlation of CSA and CSB with NH. Statistical significance is seen for both CSA and CSB. CONCLUSION Both CSA and CSB are equally effective in predicting NH at birth. These study variables can be considered as neonatal screening tool for NH for term neonates.

Keywords: cord blood albumin Cord blood bilirubin, neonatal hyperbilirubinemia, prediction, neonate

Edition: Volume 6 Issue 3, March 2017

Pages: 1327 - 1329

Share this Article

How to Cite this Article?

Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar, "Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20171760, Volume 6 Issue 3, March 2017, 1327 - 1329

Enter Your Registered Email Address





Similar Articles with Keyword 'neonatal hyperbilirubinemia'

Downloads: 128 | Weekly Hits: ⮙6 | Monthly Hits: ⮙16

Research Paper, Pediatrics, India, Volume 6 Issue 3, March 2017

Pages: 1327 - 1329

Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia

Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar

Share this Article

Downloads: 176 | Weekly Hits: ⮙2 | Monthly Hits: ⮙16

Research Paper, Pediatrics, India, Volume 4 Issue 7, July 2015

Pages: 752 - 758

Electrolyte Changes Following Phototherapy in Neonatal Hyperbilirubinemia

Dr. A. Thirupathi Reddy, Dr. K. Vani Bai, Dr. S. Uday Shankar

Share this Article

Similar Articles with Keyword 'prediction'

Downloads: 128 | Weekly Hits: ⮙6 | Monthly Hits: ⮙16

Research Paper, Pediatrics, India, Volume 6 Issue 3, March 2017

Pages: 1327 - 1329

Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia

Dr. Poonam Thakur, Dr. Roopa. B. Mangashetty, Dr. Shivshakti D. Pawar

Share this Article

Downloads: 132 | Weekly Hits: ⮙6 | Monthly Hits: ⮙15

Research Paper, Pediatrics, Iraq, Volume 6 Issue 8, August 2017

Pages: 179 - 183

Outcome Prediction of Acute Lymphoblastic Leukemia Using Nutritional Backgrounds

Hayder H. Al-Momen, Husamuldeen H. Shallal, Sawsan S. Abbas

Share this Article

Downloads: 135 | Weekly Hits: ⮙1 | Monthly Hits: ⮙5

Research Paper, Pediatrics, India, Volume 4 Issue 8, August 2015

Pages: 311 - 314

Role of Micro- ESR in the Evaluation of Suspected Sepsis in Neonates

Ghaliyah Aziz Kutty, Anitha S Prabhu, Sahana K S

Share this Article

Downloads: 164 | Weekly Hits: ⮙6 | Monthly Hits: ⮙18

Research Paper, Pediatrics, India, Volume 6 Issue 1, January 2017

Pages: 290 - 295

Yale Observation Score for Prediction of Critical Illness in 3-36 Months Old Febrile Children

Dr Karuna Thapar, Dr Preeti Malhotra, Dr Ishpreet Singh

Share this Article

Similar Articles with Keyword 'neonate'

Downloads: 21 | Monthly Hits: ⮙21

Research Paper, Pediatrics, India, Volume 10 Issue 4, April 2021

Pages: 686 - 689

Effect of Timing of Umbilical Cord Clamping on Neonatal Jaundice in Preterm Newborns between Gestational Age 32-36 Weeks: An Observational Study

Dr. Nidhi Rao, Dr. Bhawna Dubey, Dr. Sushma Nangia

Share this Article

Downloads: 40

Research Paper, Pediatrics, India, Volume 6 Issue 11, November 2017

Pages: 259 - 262

Anaesthetic Management of Neonate with Giant Occipital Meningoencephalocele: Case Report

Dr. Rajan Pandya; Dr. Suman Sahu; Dr. Olvyna D'Souza; Dr. Samrajni Ganguly

Share this Article

Downloads: 84 | Weekly Hits: ⮙1 | Monthly Hits: ⮙8

Research Paper, Pediatrics, Nepal, Volume 9 Issue 7, July 2020

Pages: 1595 - 1597

Neonatal Sepsis and Associated Factors of New Born Child in Pokhara Academy of Health Sciences, Pokhara, Nepal

Dr. Yagya Raj Sigdel, Dr. Ramchandra Bastola, Dr. Shree Krishna Shrestha, Dr. Amrita Ghimireand, Dr. Sunita Ghimire

Share this Article

Downloads: 101 | Weekly Hits: ⮙4 | Monthly Hits: ⮙10

Case Studies, Pediatrics, India, Volume 5 Issue 4, April 2016

Pages: 1786 - 1788

Citrobacter Meningitis with Encapsulated Brain Abscesses in a 6 day Old Neonate

Dr Roosy Aulakh MD, Dr. Manu Sharma MD, Dr. Jagdish Chander

Share this Article

Downloads: 103 | Weekly Hits: ⮙1

Research Paper, Pediatrics, India, Volume 4 Issue 8, August 2015

Pages: 1396 - 1400

A Study to Evaluate the Effectiveness of Sucking Stimulation Techniques on Sucking Reflex among Neonates Born at Selected Hospitals

Kaur Charanpreet, Sharma Mukesh Chandra, Singh Harijot

Share this Article



Top