Emergence of Antibiotic Resistance and Correlation with the Efflux Pump in Pseudomonas aeruginosa Isolated from Abidjan Hospital
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Biology | Congo | Volume 6 Issue 3, March 2017

Emergence of Antibiotic Resistance and Correlation with the Efflux Pump in Pseudomonas aeruginosa Isolated from Abidjan Hospital

Prisca Nicole Nieko Dangui Makaya, Nathalie Kouadio Guessennd, Christian Aime Kayath, Karine Kossia Gba, Valerie Gbonon, Simon-Pierre Assavon Nguetta, Mireille Dosso

Emergence of antibiotic resistance of Pseudomonas aeruginosa clinical strains is increasingly becoming a public health trouble shooting. The main objectives of the present study were to determine the resistance levels of different antibiotics used in therapy and to correlate the expression of four efflux pumps genes with the phenotypic resistance to antibiotics. 208 isolates of P. aeruginosa from the various biological products, stored from January 2012 to December 2015 at the Center of Biological Resources (CeReB) of the Institut Pasteur of C?te d'Ivoire have been assessed to clearly understand sensitivity of 14 antibiotics using diffusion method. As results, this work highly showed a clear emergence as regards the resistance of P. aeruginosa strains to the different classes of selected antibiotics. Nevertheless, high resistance was preferentially observed for ?-lactams, in particular for ticarcillin (30.77%). Colistin (2,4%) was the most active antibiotic in this study. This work also demonstrated the correlation between the P. aeruginosa strains resistance and the efflux pump mechanism using RT-PCR techniques. 83% of the ticarcillin-resistant strains expressed the constitutive mexB gene, 52% cefepime- resistant strains expressed regulated mexD gene, 59% of imipenem and ciprofloxacin-resistant strains expressed regulated mexF gene and finally 62% of gentamicin-resistant strains could express constitutive mexY gene.

Keywords: Emergence, Antibiotic, resistance, Pseudomonas aeruginosa, efflux pump

Edition: Volume 6 Issue 3, March 2017

Pages: 481 - 490

Share this Article

How to Cite this Article?

Prisca Nicole Nieko Dangui Makaya, Nathalie Kouadio Guessennd, Christian Aime Kayath, Karine Kossia Gba, Valerie Gbonon, Simon-Pierre Assavon Nguetta, Mireille Dosso, "Emergence of Antibiotic Resistance and Correlation with the Efflux Pump in Pseudomonas aeruginosa Isolated from Abidjan Hospital", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20171420, Volume 6 Issue 3, March 2017, 481 - 490

94 PDF Views | 88 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Emergence'

Informative Article, Biology, India, Volume 3 Issue 12, December 2014

Pages: 1053 - 1057

Into the Pigmentation of Fish: A Physiological Perspective

Tincy Varghese, Sanal Ebeneezar, Sreekanth G. B., Mishal P

Share this Article

Review Papers, Biology, India, Volume 4 Issue 6, June 2015

Pages: 1482 - 1485

An Insight into the Cell Wall of Mycobacterium Tuberculosis

Gaurav Tyagi, SakshiTalwar, Parveen Garg

Share this Article

Case Studies, Biology, Kosovo, Volume 4 Issue 7, July 2015

Pages: 560 - 562

The presence of Salmonella Enteritidis in Faecal Samples, Eggs and Poultry Bodies Isolated for Egg Production in Some Regions (Lipjan, Shtime and Ferizaj) of Kosovo

Hyzer Rizani, Pranvera Cabeli

Share this Article

Research Paper, Biology, Congo, Volume 6 Issue 3, March 2017

Pages: 481 - 490

Emergence of Antibiotic Resistance and Correlation with the Efflux Pump in Pseudomonas aeruginosa Isolated from Abidjan Hospital

Prisca Nicole Nieko Dangui Makaya, Nathalie Kouadio Guessennd, Christian Aime Kayath, Karine Kossia Gba, Valerie Gbonon, Simon-Pierre Assavon Nguetta, Mireille Dosso

Share this Article

Review Papers, Biology, Morocco, Volume 9 Issue 4, April 2020

Pages: 453 - 457

COVID-19 : A Global Emergency and a Common Destiny between the Nations

H Chemsi, S Ibnmoussa, Y Sekhsokh, N Khlil

Share this Article

Similar Articles with Keyword 'Antibiotic'

Review Papers, Biology, Azerbaijan, Volume 5 Issue 4, April 2016

Pages: 2276 - 2279

Modern Conceptions about Antibiotic Levorin A and its Derivatives Action in Cell and Bilayer Lipid Membranes

Dr. Samedova Arifa Ali Hasan, Dr. Sultanova Gulnar Hadjibek

Share this Article

Research Paper, Biology, India, Volume 3 Issue 7, July 2014

Pages: 488 - 489

Antibiotic Sensitivity Test on E. coli Isolates from Different Sources

Sumona Chakrabortty, Dr. Rachana Choudhary, Dr. Sonia Bajaj

Share this Article

Research Paper, Biology, India, Volume 3 Issue 8, August 2014

Pages: 1972 - 1974

Inhibition of Antibiofilm Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens by Vitex Trifolia

R. Nancy Immaculate Mary, N. Banu

Share this Article

Research Paper, Biology, India, Volume 3 Issue 6, June 2014

Pages: 1111 - 1120

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Share this Article

Research Paper, Biology, India, Volume 4 Issue 4, April 2015

Pages: 1950 - 1954

An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime

Deepak Tom Jose, Caroline Nirmala. R

Share this Article

Similar Articles with Keyword 'resistance'

Informative Article, Biology, Tanzania, Volume 3 Issue 7, July 2014

Pages: 1150 - 1154

In vitro Antibacterial and Antifungal Activity of Tanzanian Bersama abyssinica

Never Zekeya, Francis Shahada, Musa Chacha

Share this Article

Research Paper, Biology, India, Volume 3 Issue 8, August 2014

Pages: 1972 - 1974

Inhibition of Antibiofilm Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens by Vitex Trifolia

R. Nancy Immaculate Mary, N. Banu

Share this Article

Research Paper, Biology, Iraq, Volume 4 Issue 4, April 2015

Pages: 2652 - 2656

ABO Blood Group System Polymorphism and its Relation to Diseases Affection in Diyala Province

S. H. Alsamarrae Anas A. Humadi

Share this Article

Review Papers, Biology, India, Volume 3 Issue 9, September 2014

Pages: 2238 - 2245

Diabetes and Progression of Alzheimer?s: Linking the Two Epidemics

Dr. S. S. Bandyopadhyay, Hiral Mistry, Rudra Prasad Dutta

Share this Article

Review Papers, Biology, India, Volume 4 Issue 6, June 2015

Pages: 1482 - 1485

An Insight into the Cell Wall of Mycobacterium Tuberculosis

Gaurav Tyagi, SakshiTalwar, Parveen Garg

Share this Article

Similar Articles with Keyword 'Pseudomonas aeruginosa'

Research Paper, Biology, India, Volume 3 Issue 3, March 2014

Pages: 706 - 708

Phytochemical Analysis and Antimicrobial Activity of Spaghetti Squash towards Some Pathogenic Microbes

P. Rama Devi, C. Babu, P. Kombiah

Share this Article

Research Paper, Biology, India, Volume 2 Issue 1, January 2013

Pages: 576 - 580

Bio prospecting Mokkathotakalli Leaves of Piper Betel L. Cv. Kapoori as a Potential Source of Anti Microbial Agents against selected Bacterial Strains

Lydia Swapna Nandam, Hari Krishna Rama Prasad, Ammani Kandru

Share this Article

Research Paper, Biology, Iraq, Volume 7 Issue 1, January 2018

Pages: 1440 - 1445

Study the Effect of Pomegranate (Punica granatum) Peel Extracts on Some Physiological Characters of Pseudomonas aeruginosa

Najlaa Nabhan Yaseen, Fatima Hassan Ali

Share this Article

Research Paper, Biology, Congo, Volume 6 Issue 3, March 2017

Pages: 481 - 490

Emergence of Antibiotic Resistance and Correlation with the Efflux Pump in Pseudomonas aeruginosa Isolated from Abidjan Hospital

Prisca Nicole Nieko Dangui Makaya, Nathalie Kouadio Guessennd, Christian Aime Kayath, Karine Kossia Gba, Valerie Gbonon, Simon-Pierre Assavon Nguetta, Mireille Dosso

Share this Article

Research Paper, Biology, India, Volume 4 Issue 8, August 2015

Pages: 338 - 340

Antibacterial Principles of Salacia oblonga WALL Extracts against Drug Resistance Pathogens

Anjaneyulu Musini, Archana Giri

Share this Article
Top