International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 134

Research Paper | Medicine Science | Indonesia | Volume 6 Issue 3, March 2017


Up-regulation of p27Kip1 and Caspase-9 Expression in Oral Malignant Burkitt's Lymphoma Cell Induced by 3,4-dihydro-6-[4-{3,4-dimethoxybenzoyl}-1-piperazinyl]-2(1H)-quinolinone-vesnarinone (Studyon chemotactic migration and apoptosis cell)

Supriatno [5]


Abstract: Oral Burkitts lymphoma is an uncommon type of Non-Hodgkin lymphoma (NHL) commonly affects at children. It is a highly aggressive type of B-cell lymphoma. Treatment for this tumor is still limited. However, a new strategy for refractory tumor, synthetic drug from natural herbal has watched with keen interest. In the present study, various concentrations of docetaxel hidrate were incubated into an oral Burkitts lymphoma (Raji) cell line. The aim of the study was to examine the docetaxel hydrate induces chemotactic migration barrier and apoptosis in an oral Burkitts lymphoma cell. The efficiency of docetaxel hydrate in the suppression of cell chemotactic migration was examined by Boyden chamber assay. To evaluate the induction of apoptosis was carried-out by caspase-9 colorimetric assay and double staining acridine orange-ethidium bromide. The results of the study revealed the cell chemotactic migration activity were markedly suppressed by docetaxel hydrate followed by the induction of apoptosis through caspase-9 activity and double staining assay. These results suggest that docetaxel hydrate had a potential as an antitumor proofed by induction of chemotactic migration barrier and of apoptosis in an oral Burkitts lymphoma cells.


Keywords: Docetaxel hydrate, chemotactic migration, apoptosis, Burkitts lymphoma cell


Edition: Volume 6 Issue 3, March 2017,


Pages: 428 - 432


How to Cite this Article?

Supriatno, "Up-regulation of p27Kip1 and Caspase-9 Expression in Oral Malignant Burkitt's Lymphoma Cell Induced by 3,4-dihydro-6-[4-{3,4-dimethoxybenzoyl}-1-piperazinyl]-2(1H)-quinolinone-vesnarinone (Studyon chemotactic migration and apoptosis cell)", International Journal of Science and Research (IJSR), Volume 6 Issue 3, March 2017, pp. 428-432, https://www.ijsr.net/get_abstract.php?paper_id=ART20171402

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'apoptosis'

Downloads: 82

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 12, December 2015

Pages: 1639 - 1644

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitts Lymphoma Cells

Supriatno [5] | Sartari Entin Yuletnawati [3]

Share this Article

Downloads: 105

Research Paper, Medicine Science, Egypt, Volume 4 Issue 2, February 2015

Pages: 1615 - 1619

Urinary Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) As a Marker for Lupus Nephritis Activity

Mohamed Elsayed [3] | Khaled A. Elhefnawy | Anas A. Qassem | Ghada E. Amr

Share this Article


Top