International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 158

Research Paper | Medicine Science | Indonesia | Volume 5 Issue 7, July 2016


Inhibition and Anti Proliferation Human Tongue Cancer Cells Supri's Clone-1 Invasion with Cyclooxygenase-2 Inhibitor

Harun Achmad, Supriatno


Abstract: The aim of this study was to examine inhibition and proliferation of tongue cancer cells by using the SP - C1 chemopreventive drug, Celecoxib. In the method of invasion, tongue cancer cells treated with SP - C1 Celecoxib at concentrations of 5 m, 10 m, 25 m, 50 m, 75 m, 100 m and 125 m, and 0 as the control group. Tests were carried out for 24 and 48 hours with the calculation of the mean tongue cancer cell invasion SP-C1. Invasion tests used Boyden Chamber Assay and polycarbonate membrane. In proliferation test, Tongue cancer cells SP-C1 were treated with various concentrations of Celecoxib and time.192 cancer cells was grouped in 4 different groups of observation time, each group have 8 cancer cells, one without Celecoxib treatment (control), 5 m, 10 m, 25 m, 50 m, 75 m, 100 m and 125 m. Mean growth inhibition of cancer cells SP-C1 was calculated using Biorad Microplate Reader 540 nm. The results of the study showed the average number of tongue cancer cell invasion SP-C1 after the administration Celecoxib based on the concentration and time with ANOVA gives F = 60.46, which statistically significant. In zero concentration of Celecoxib (control) was 24.4 with Celecoxib concentrations ranging from 5 to 125 had decreased from an average of 11 to 2.3. In a proliferation test, results were statistically significant. Time factor (calculated F = 45.78), concentration factor (F count = 17.77), and time and concentration interaction (F count = 46.64) had showed the effect of different views of the average cell growth inhibition. The conclusion of this research Celecoxib delivery on tongue cancer cells showed SP - C1 barriers invasion and proliferation. Greater concentration of Celecoxib administered will provide a greater effect on the barrier invasion and proliferation of tongue cancer cells SP-C1.


Keywords: Invasion, Proliferation, Cancer Cells tongue SP-C1, Celecoxib


Edition: Volume 5 Issue 7, July 2016,


Pages: 55 - 59


How to Cite this Article?

Harun Achmad, Supriatno, "Inhibition and Anti Proliferation Human Tongue Cancer Cells Supri's Clone-1 Invasion with Cyclooxygenase-2 Inhibitor", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART201676, Volume 5 Issue 7, July 2016, 55 - 59

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Invasion'

Downloads: 103

Research Paper, Medicine Science, Bulgaria, Volume 5 Issue 2, February 2016

Pages: 1460 - 1464

Analysis of Microbiological Results in Teeth with Chronic Apical Periodontitis

Angela Gusiyska, Stefan Peev

Share this Article

Downloads: 106

Case Studies, Medicine Science, Saudi Arabia, Volume 7 Issue 9, September 2018

Pages: 597 - 61

A Fatal Outcome of Rhino-Orbital-Cerebral Mucormycosis in Newly Diagnosed Diabetic Patient

Alkhamis Mohammed, Almomen Ali, Molani Fadel, Alhubail Rasheed

Share this Article

Similar Articles with Keyword 'Proliferation'

Downloads: 106

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 8, August 2015

Pages: 1675 - 1678

The Role of Inflammation in the Benign Prostatic Hyperplasia Pathogenesis

Amir Azwar, Yusuf Irawan, Patellongi Ilhamjaya, Sinrang Wardihan, Rasyid Nur

Share this Article

Downloads: 111

Comparative Studies, Medicine Science, India, Volume 4 Issue 3, March 2015

Pages: 1736 - 1738

Comparative Efficacy of Electrosurgery with Topical 50% Trichloroacetic Acid in Treatment of Warts

Harika C, Sankeerth V

Share this Article
Top