International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 136

Research Paper | Biology | India | Volume 6 Issue 1, January 2017


Studies on Drug Delivery Efficacy of Silver Nanoparticles Synthesized using Human Serum Albumin as Tamoxifen Carriers in MCF-7 Cell Line

V. Pradeepa, T. Sriram, M. Sujatha


Abstract: A simple and convenient method is synthesis of silver Nanoparticles (AgNps) in a foam matrix using the protein Human serum albumin (HSA) is reported. HAS is an excellent foaming agent and by virtue of its zwitter ionic character at the protein isoelectric point, may be used to bind to cationic silver (Ag+) ions in the foam. The metal ions in the foam are thereafter reduced in situ to yield silver Nanoparticles. The HAS molecules coat and stabilize the Nanoparticles thus eliminating the necessity of employing an additional stabilizing agent in the experimental procedure. The synthesized Nanoparticles where characterized by UV-visible spectroscopy, X-ray diffraction (XRD), Scanning electron microcopy (SEM), energy-dispersive X-ray spectrometry (EDAX) and Fourier-transform infrared spectroscopy (FTI) with silver Nanoparticles of 20-30nm were obtained invitro cytotoxic studies revealed that the silver Nanoparticles shows Significant growth inhibition in dose dependent manner.


Keywords: Silver Nanoparticles, Human Serum Albumin, MCF-7, Cancer, MTT Assay, FTIR


Edition: Volume 6 Issue 1, January 2017,


Pages: 1881 - 1888


How to Cite this Article?

V. Pradeepa, T. Sriram, M. Sujatha, "Studies on Drug Delivery Efficacy of Silver Nanoparticles Synthesized using Human Serum Albumin as Tamoxifen Carriers in MCF-7 Cell Line", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20164509, Volume 6 Issue 1, January 2017, 1881 - 1888

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Silver Nanoparticles'

Downloads: 106

Research Paper, Biology, India, Volume 3 Issue 10, October 2014

Pages: 2238 - 2243

Biogenic Synthesis of Silver Nanoparticles using Leaves of Crinum asiaticum Linn.

Malathi. R, Ganesan. V

Share this Article

Downloads: 114

Research Paper, Biology, India, Volume 3 Issue 11, November 2014

Pages: 1424 - 1430

Antimicrobial Activity & Anti Oxidant Activity of Extracellularly Synthesized Silver Nanoparticles from Marine Derived Aeromonas salmonicida

Pradeepa V., Saranya N

Share this Article

Similar Articles with Keyword 'MCF7'

Downloads: 132

Research Paper, Biology, India, Volume 4 Issue 12, December 2015

Pages: 48 - 51

Evaluation of Adenanthera pavonina Bark Extracts for Antioxidant Activity and Cytotoxicity against Cancer Cell Lines

Renilda Sophy A. J., Albin T. Fleming

Share this Article

Downloads: 132

Research Paper, Biology, India, Volume 6 Issue 1, January 2017

Pages: 1310 - 1316

Antioxidant and Anticancer Activities of Methanol Extract of Melochia corchorifolia L.

Harini.V, Vijayalakshmi.M, Sivaraj.C, Arumugam.P

Share this Article

Similar Articles with Keyword 'Cancer'

Downloads: 105

Research Paper, Biology, India, Volume 5 Issue 11, November 2016

Pages: 726 - 732

Biosynthesis of Omega 3fatty Acids and the Activation of Anticancerous Effect in Human

Dr. Y. Thangam, B. Ranchitha

Share this Article

Downloads: 107

Research Paper, Biology, India, Volume 4 Issue 12, December 2015

Pages: 1362 - 1366

New Aryl Derivatives of Acridine with Poly (ADP- Ribose) Polymerase 1 Inhibitory Activity: A Molecular Modeling Approach

Sayantani Karmakar, Rita Ghosh

Share this Article

Similar Articles with Keyword 'MTT Assay'

Downloads: 110

Research Paper, Biology, India, Volume 4 Issue 12, December 2015

Pages: 1405 - 1408

Cytotoxicity Analysis of Crude Leaf Extracts from Tecoma castanifolia (D. Don) Melch on Brine Shrimp and MCF-7 Cell Line

R. Vidhya, Dr. Albin T. Fleming

Share this Article

Downloads: 132

Research Paper, Biology, India, Volume 6 Issue 1, January 2017

Pages: 1310 - 1316

Antioxidant and Anticancer Activities of Methanol Extract of Melochia corchorifolia L.

Harini.V, Vijayalakshmi.M, Sivaraj.C, Arumugam.P

Share this Article

Similar Articles with Keyword 'FTIR'

Downloads: 108

Research Paper, Biology, India, Volume 4 Issue 5, May 2015

Pages: 1697 - 1702

Biodegradation of Reactive Dyes by Two Microalgal Species

Dr. N. H. Brahmbhatt, Dr. R. T. Jasrai

Share this Article

Downloads: 114

Research Paper, Biology, India, Volume 3 Issue 11, November 2014

Pages: 1424 - 1430

Antimicrobial Activity & Anti Oxidant Activity of Extracellularly Synthesized Silver Nanoparticles from Marine Derived Aeromonas salmonicida

Pradeepa V., Saranya N

Share this Article

Similar Articles with Keyword 'Silver'

Downloads: 106

Research Paper, Biology, India, Volume 3 Issue 10, October 2014

Pages: 2238 - 2243

Biogenic Synthesis of Silver Nanoparticles using Leaves of Crinum asiaticum Linn.

Malathi. R, Ganesan. V

Share this Article

Downloads: 114

Research Paper, Biology, India, Volume 3 Issue 11, November 2014

Pages: 1424 - 1430

Antimicrobial Activity & Anti Oxidant Activity of Extracellularly Synthesized Silver Nanoparticles from Marine Derived Aeromonas salmonicida

Pradeepa V., Saranya N

Share this Article

Similar Articles with Keyword 'Nanoparticles'

Downloads: 106

Research Paper, Biology, India, Volume 3 Issue 10, October 2014

Pages: 2238 - 2243

Biogenic Synthesis of Silver Nanoparticles using Leaves of Crinum asiaticum Linn.

Malathi. R, Ganesan. V

Share this Article

Downloads: 107

Research Paper, Biology, India, Volume 3 Issue 11, November 2014

Pages: 1703 - 1707

Design of Aptamer-Gold Nanoparticles Based Colorimetric Assay for the Early Diagnosis of Breast Tumor

Nandita P. Agnihotri, Mangla Bhide

Share this Article

Similar Articles with Keyword 'Human'

Downloads: 140 | Monthly Hits: ⮙1

Research Paper, Biology, India, Volume 6 Issue 11, November 2017

Pages: 942 - 945

Study of Contaminated Currency Notes in Circulation

Tushar Chandrakant Mhatre

Share this Article

Downloads: 5 | Weekly Hits: ⮙2 | Monthly Hits: ⮙5

Informative Article, Biology, United States of America, Volume 10 Issue 10, October 2021

Pages: 33 - 35

COVID-19 Vaccines: A Path to Normalcy at HBCUs

Lawrence O. Flowers

Share this Article

Similar Articles with Keyword 'Serum'

Downloads: 101

Research Paper, Biology, Iraq, Volume 3 Issue 9, September 2014

Pages: 1145 - 1148

Immunological Study of Women Infected with Trichomonas vaginalis Parasite in Baghdad city

Mohammed Jasim Shaker, Rawaa Abdulkhaleq Hussein

Share this Article

Downloads: 107

Research Paper, Biology, India, Volume 4 Issue 11, November 2015

Pages: 1544 - 1551

Analysis of Monolaurin, Beta- Carotene, Weakened Beta-Carotene and their Antagonistic Properties with HIV: An Exploratory Study

Paul Inbaraj.

Share this Article

Similar Articles with Keyword 'Albumin'

Downloads: 111

Research Paper, Biology, Libya, Volume 4 Issue 8, August 2015

Pages: 1040 - 1048

Sodium Nitrite Induced Biochemical Alterations in the Blood Serum and its Amelioration by Aqueous Extract of Libyan Propolis in Guinea Pigs

Gamal J. A. Aboulgasem, Azab El-Sayed Azab, Mahdi M. Almaky

Share this Article

Downloads: 113

Research Paper, Biology, India, https://www.ijsr.net/issue.php?edition=Volume%203%20Issue%208,%20August%20201

Pages: 1911 - 1914

Haematological and Serum Biochemical Parameters in different Sexes of Walking Cat Fish, Clarias batrachus (Linnaeus, 1758)

Gayatri Acharya, Prafulla K. Mohanty

Share this Article
Top