International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 160

Research Paper | Biochemistry Science | India | Volume 6 Issue 1, January 2017


HPLC, UV Spectrum Analysis of Polyherbal Formulation and DNA Damage in Hepatoprotective CCl4 Induced Albino Rats

A Dhinek, C Sowmia


Abstract: The objective of this study was to investigate the hepatoprotective activity of ethonolic extract of polyherbalformulation (Solanumxanthocarpum, Glycyrrhizaglabra, Ricinuscommunis, and Phyllanthusniruri leaves) against carbon tetrachloride (CCl4) induced hepatotoxicity. The plants were dried in shade then powdered, extracted with ethanol. Preliminary phytochemical tests were done with the ethanolic extract showed presence of mostly all the compounds. The hepatoprotective activity of the ethonolic extract was assessed in CCl4 induced hepatotoxic albino rats. HPLC and UV spectrum analysis revealed to identify and to quantify each component. The present study that exhibit free radical scavenging properties. DNA damage in liver was also evaluated using Comet assay. The DNA damages and the length are tested, Progression of liver damage induced by CCl4 in albino rats can be intervened using the polyherbal extract and these effects are comparable to those of silymarin, polyherbal treatments effectively restored these measurements closer to their normal levels.


Keywords: Hepatoprotection, Hepatotoxicity, CCl4, Sylimerin, Polyherbal drugs


Edition: Volume 6 Issue 1, January 2017,


Pages: 129 - 132


How to Cite this Article?

A Dhinek, C Sowmia, "HPLC, UV Spectrum Analysis of Polyherbal Formulation and DNA Damage in Hepatoprotective CCl4 Induced Albino Rats", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20163942, Volume 6 Issue 1, January 2017, 129 - 132

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Hepatotoxicity'

Downloads: 109

Research Paper, Biochemistry Science, Nigeria, Volume 4 Issue 7, July 2015

Pages: 1400 - 1406

Ameliorative Effects of Methanolic Extract of Sennaalataleaves on Streptozotocin (Stz)-Induced Oxidative Stress and Hepatotoxicity in Adult Wistar Albinorats

Akintola A.O, Adedosu O.T, Kehinde B.D, Ibikunle G.J

Share this Article

Downloads: 133

Research Paper, Biochemistry Science, India, Volume 5 Issue 3, March 2016

Pages: 2213 - 2220

A Comparative Study of the Role of Various Antibiotic Drugs in Drug Induced Liver Injury by Hepatotoxicity

Rajesh K. Bhaskar

Share this Article

Similar Articles with Keyword 'CCl4'

Downloads: 117

M.Tech / M.E / PhD Thesis, Biochemistry Science, Nigeria, Volume 5 Issue 2, February 2016

Pages: 2036 - 2040

Effect of Methanol Root Extract of Senna occidentalis against Carbon Tetrachloride-Induced Hepatic Damage in Rats

Kwalle Joseph John, Bello M. I.

Share this Article

Downloads: 132

Research Paper, Biochemistry Science, Nigeria, Volume 5 Issue 5, May 2016

Pages: 56 - 61

The Amelioration of Carbon Tetracholride ? Induced Toxicities by Methanolic Extract of Buchholzia coriacea Leave in Male Albino Rat

AKINYEDE Kolajo.A, OYEWUSI Habeebat.A, OLOGUNDE Charles.A, ADENIYI Olayemi.A

Share this Article
Top