Immunohistochemical Expression of P53 in Colorectal Tumors among Sudanese Patients
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Histopathology | Sudan | Volume 5 Issue 12, December 2016

Immunohistochemical Expression of P53 in Colorectal Tumors among Sudanese Patients

Ahmed Hasan Ahmed Guzailan, Mohammed Siddig Abdal-Aziz, Ahmed Abde lbadie Mohammed, Mai Abdul Rahman Masri

Previous studies have suggested that p53 immunostaining may provide useful prognostic data in colorectal cancer. The aim of the study was to detect the immunohistochemical expression of p53 tumor marker in colorectal tumors among Sudanese patients. Retrospective analytical case control study design was used in this study. Formalin-fixed paraffin-embedded tissue block samples from 150 colorectal tumor patients including 100 malignant tissue blocks and 50 benign tissue blocks of colorectal tumors from Ibn Sina Hospital and Soba Teaching Hospital at Khartoum stat were analyzed for P53 using Immunohistochemical detection. The Immunohistochemical expression of p53 was positive in 61 % of malignant tumor tissues, while none of the benign tumor samples was positive for this marker with significant relation between immunohistochemical expression and histopathological diagnosis (p= 0.000). The majority of samples with p35 expression were either moderately differentiated tumors or well differentiated tumors (63.5 % and 61 % respectively) while only 50 % of samples were classified as poorly differentiated tumors with no significant relation between the immunohistochemical expression of p53 and cancer grade (p= 0.776). Conclusion Immunohistochemical expression of P53 was exclusively detected in colorectal malignant tumors providing a useful marker for the carcinogenesis of colorectal tumors. However, immunohistochemical expression of P53 did not affect histological grade of tumors and cannot be used for grading and hence prognosis. Several other markers are needed to be used in combination with p53 to improve colorectal tumor diagnosis among Sudanese.

Keywords: Immunohistochemical, p53, colorectal tumor

Edition: Volume 5 Issue 12, December 2016

Pages: 1829 - 1832

Share this Article

How to Cite this Article?

Ahmed Hasan Ahmed Guzailan, Mohammed Siddig Abdal-Aziz, Ahmed Abde lbadie Mohammed, Mai Abdul Rahman Masri, "Immunohistochemical Expression of P53 in Colorectal Tumors among Sudanese Patients", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20163845, Volume 5 Issue 12, December 2016, 1829 - 1832

51 PDF Views | 46 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Immunohistochemical'

Research Paper, Histopathology, Iraq, Volume 6 Issue 2, February 2017

Pages: 1768 - 1772

Histological and Immunohistochemical (ANXA1) Analysis of Bisphosphonate (Zoledronate) Effect on Submandibular and Parotid Glands in Neonatal Rats

Essa Hasan Essa, Nada M.H. Al-Ghaban

Share this Article

Research Paper, Histopathology, Sudan, Volume 5 Issue 12, December 2016

Pages: 1829 - 1832

Immunohistochemical Expression of P53 in Colorectal Tumors among Sudanese Patients

Ahmed Hasan Ahmed Guzailan, Mohammed Siddig Abdal-Aziz, Ahmed Abde lbadie Mohammed, Mai Abdul Rahman Masri

Share this Article

Research Paper, Histopathology, Iraq, Volume 6 Issue 8, August 2017

Pages: 478 - 483

Immunohistochemical Detection of BRAF in Iraqi Women with Different Breast Tumors

Ban Jasim Mohamad, Reyadh Salim Mohammed, Sajed Saad Mohammed, Faeza AftanZghair, Haneen Husam Mahmoud, Maryem Faris Hameed

Share this Article

Research Paper, Histopathology, Indonesia, Volume 7 Issue 6, June 2018

Pages: 245 - 248

The Association between CD10 Expression and Histological Grade in Invasive Breast Carcinoma of No Special Type

I Gusti Ayu Ari Kusumawati, Luh Putu Iin Indrayani Maker, I Gusti Alit Artha

Share this Article

Research Paper, Histopathology, Saudi Arabia, Volume 8 Issue 1, January 2019

Pages: 323 - 327

Expression of HER2 and BRCA1 in Breast Tumors among Sudanese Women, Immunohistochemical Study

Mohamed Ahmed Mohamed Osman, Saadalnour Abusail Mustafa, Ihab Hamed Nourein Hamed, Faris Merghani Eltom, Shawgi Abdelrhman Elsiddig, Rabab Ali Alhag

Share this Article
Top