Research Paper | Pharmacology Science | India | Volume 5 Issue 12, December 2016
Inexpensive Happy Hormone ?Dopamine?-A Safe Antiangiogenic Drug & Enhancing Dopamine Levels By Mucuna Pruriens
Ayesha Sultana | K. Saraswathi 
Abstract: The research reveals that Dopamine blocks the formation of blood vessels in tumors by inhibiting the action of vascular endothelial factor and prevents the side effects associated with currently used chemotherapeutic agents. The aim of this work is to show the role of Dopamine as safe anti angiogenic agent, treating and enhancing Dopamine naturally by the tablets prepared from the powdered seed extracts of Mucuna pruriens by Wet granulation method. The tablets prepared were evaluated for pre and post compression parameters and they were within permissibe limits as per the standards. Experiments were carried out in mice and were divided into four groups. Group A-Control group, Group B-Disease induced (tumor) but no treatment, Group C-Disease induced and treatment by Standard I. V dose of Dopamine, Group D-Disease induced, it is treated with test dose of tablets of Mucuna pruriens. The tumors were induced by Benzopyrene, formation of tumors were confirmed by checking the parameters of electrolyte levels, haematology values and liver function test. The mice treated with standard dose exhibited weight gain because of retention of urine which leads to accumulation of Uric acid. Swelling and Pain is also observed at the site of injection. Mice treated with test dose showed no side effects, as Mucuna pruriens contains L-Dopa which readily crosses Blood Brain Barrier enhances Dopamine levels naturally, significantly in very economical and easy approach. The In vitro release of formulation (F3) showed 92 % drug release.
Keywords: Benzopyrene, Dopamine, Vascular Endothelial Factor, Mucuna pruriens
Edition: Volume 5 Issue 12, December 2016,
Pages: 471 - 474