International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 111

Research Paper | Biochemistry Science | India | Volume 5 Issue 8, August 2016


Induction of Enzymatic Antioxidants by Moderate Alcohol Consumption

Atteequeurrehman M. Harlapur | Shashikant V. Nikam | Padmaja S. Nikam


Abstract: Oxidative stress is implicated in the pathogenesis of atherosclerosis and myocardial infarction. Moderate alcohol consumption has various favourable metabolic changes. In this study Malondialdehyde (MDA) levels and activities of enzymatic antioxidants namely superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were determined in 120 non smoker healthy males with self reported daily consumption of 90ml or 120ml of whisky and rum.30 non smoker healthy males with no history of alcohol consumption were taken as controls. The result shows significantly elevated levels of MDA (p<0.0001) in participants consuming 120ml of whisky (6.42.2nmol/ml) and 120ml of rum (6.72.0nmol/ml) compared to those consuming 90ml of whisky (3.82.0nmol/ml) and 90ml of rum (3.91.9nmol/ml). While the activities of enzymatic antioxidants were significantly increased (p<0.0001) in participants consuming 90ml of alcohol (whisky/rum) compared to those consuming 120ml of alcohol (whisky/rum). Alcohol consumption is associated with dose dependent increase in lipid peroxidation. Moderate alcohol consumption induces defensive antioxidant enzymes, this explains the increase in activities of enzymatic antioxidants in 90ml alcohol consumers. Thus study concludes that consumption of 90ml of alcohol (whisky/rum) in a regularly exercising, non smoker will increase the enzymatic antioxidants. This will lead to reduced oxidative stress which might be the reason for eventual decrease in the risk of cardiovascular disease.


Keywords: Alcohol consumption, oxidative stress, SOD, GPX, MDA


Edition: Volume 5 Issue 8, August 2016,


Pages: 1269 - 1271

Induction of Enzymatic Antioxidants by Moderate Alcohol Consumption


How to Cite this Article?

Atteequeurrehman M. Harlapur, Shashikant V. Nikam, Padmaja S. Nikam, "Induction of Enzymatic Antioxidants by Moderate Alcohol Consumption", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20161109, Volume 5 Issue 8, August 2016, 1269 - 1271, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'oxidative stress'

Downloads: 44 | Monthly Hits: ⮙1

Review Papers, Biochemistry Science, Turkey, Volume 9 Issue 11, November 2020

Pages: 889 - 903

Understanding the Pathogenesis of Cancer as Metabolic Remodulations

Ibrahim Karidio Diori | Senay Hamarat Sanlier

Share this Article

Downloads: 94

Research Paper, Biochemistry Science, India, Volume 4 Issue 7, July 2015

Pages: 2089 - 2091

Evaluation of Malondialdehyde and Nitric Oxide and its Impact on Sperm Quality Parameters in Oligospermic Infertile Men

Dr. Kavita More | Dr. Badade ZG | Dr. Narshetty JG

Share this Article


Top